Evidence map›Paper›PMID 41329279›Full record

ArticleDoklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections2025

Dual Effects of Acetylcholine on Mast Cell-Nerve Interactions.

N A Kutukova, A S Trulioff, A V Polevshchikov, O V Shamova

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Article in Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sections, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

N A KutukovaInstitute of Experimental Medicine, St. Petersburg, Russia.
A S TrulioffInstitute of Experimental Medicine, St. Petersburg, Russia.
A V PolevshchikovInstitute of Experimental Medicine, St. Petersburg, Russia. alexpol512@yandex.ru.
O V ShamovaInstitute of Experimental Medicine, St. Petersburg, Russia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mast cell (MC)-nerve units are one of the main elements of cooperation between the nervous and immune systems, providing a structural and functional connection between MCs and autonomic nerve fibers. Although immunoregulatory activity of acetylcholine (ACh) is well established, the exact point of its influence on MCs remains unclear. This study compared the effects of muscarinic (mAChR) versus nicotinic (nAChR) ACh receptor binding on secretory activity of HMC-1 cells. It was found that ACh activates intact MCs mainly through the M3 mAChR, but suppresses degranulation in stimulated MCs via the α7 nAChR. The findings indicate that changes in the receptor pattern within MC-nerve units underlie the dual effects of ACh and enable MCs to switch functions in inflammation from proinflammatory activity in the acute phase to anti-inflammatory activity during reparation.

Indexed as

AcetylcholineMast Cellsalpha7 Nicotinic Acetylcholine ReceptorAnimalsCell DegranulationCell LineHumansReceptors, MuscarinicAcetylcholinealpha7 Nicotinic Acetylcholine ReceptorReceptors, Muscarinicacetylcholineacetylcholine receptorshistaminemast cell–nerve unitmast cellsneural–immune interactions

Identifiers

PMID41329279

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.