Evidence map›Paper›PMID 41329231›Full record

ArticleMolecular biology reports2025

The influence of blood levels of circRNAs and microRNAs on the development of ulcerative colitis.

Mai A H Abouelenin, Safaa I Tayel, Amany A Saleh, Naglaa S Elabd, Randa M Seddik, Eman A El-Masry, Mahmoud Rizk, Osama Elbahr, Huda I Abd-Elhafiz, Mohammed G Elhelbawy and 2 more

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Article in Molecular biology reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

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12 authors.

Mai A H AboueleninMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Safaa I TayelMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt. drsafaa_tayel@yahoo.com.ORCID http://orcid.org/0000-0002-6528-0256
Amany A SalehMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Naglaa S ElabdTropical Medicine Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Randa M SeddikTropical Medicine Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Eman A El-MasryMedical Microbiology and Immunology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Mahmoud RizkInternal Medicine Department, Faculty of Medicine, Benha University, Banha, Egypt.
Osama ElbahrHepatology and Gastroenterology Department, National Liver Institute - Menoufia University, Cairo, Egypt.
Huda I Abd-ElhafizClinical Pharmacology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Mohammed G ElhelbawyClinical Pathology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Ghada E ElgarawanyMedical Physiology Departement, Faculty of Medicine, Menoufia University, Cairo, Egypt.
Heba F KhaderMedical Biochemistry and Molecular Biology Department, Faculty of Medicine, Menoufia University, Cairo, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundUlcerative colitis is an inflammatory condition of the colon with an unknown cause. It is the most common form of inflammatory bowel disease worldwide, typically starting in the rectum and extending continuously through the mucosa and submucosa of the colon. A primary genetic component or disturbed gut microbiota may precipitate the disease.

methodsWe are investigating the roles of circRNAs and microRNAs in the disease, focusing on their connections to severity and remission. We used real-time PCR to measure the expression levels of selected microRNAs (miR-29a, miR-30c, miR-148a, and miR-410-3p) and the circRNA met oncogene and circ 0084764 in peripheral blood.

resultsFecal calprotectin was elevated in the severe group than in the mild group (p = 0.005). MicroRNA-29a was significantly upregulated in the severe group compared to the mild group (p = 0.016). MicroRNA-30c was significantly downregulated in the severe group compared to the mild group (p = 0.004). MicroRNA-410-3p was downregulated in the severe group compared to both the mild and moderate groups (p < 0.001 and p = 0.022), respectively. Conversely, microRNA-148a exhibited no significant alterations among the patient groups (p = 0.318). CircRNA-0084764 was upregulated in the severe group compared to the mild and moderate groups (p < 0.001 and p = 0.001), respectively. The diagnostic performance of markers in distinguishing patients from controls showed that circRNA-met oncogene had the highest sensitivity of 94.83% and a specificity of 100%.

conclusionWe confidently established that the altered expression of circRNAs and microRNAs contributes to UC’s pathogenesis and drug therapy’s personalization. Notably, circRNA-met oncogene stands out as an independent predictor of disease severity, while microRNA-30c is a proven and reliable independent remission predictor.

Indexed as

Colitis, UlcerativeMicroRNAsRNA, CircularAdultBiomarkersFemaleHumansMaleMiddle AgedProto-Oncogene Proteins c-metBiomarkersMET protein, humanMicroRNAsMIRN148 microRNA, humanMIRN29a microRNA, humanMIRN30a microRNA, humanProto-Oncogene Proteins c-metRNA, CircularCircRNA-0084764CircRNA-met oncogeneMicroRNA-148aMicroRNA-29aMicroRNA-30cMicroRNA-410-3pUlcerative colitis

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PMID41329231

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.