Evidence map›Paper›PMID 41329223›Full record

SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025

Comparison of different exercise modalities on chronic inflammation and immune function in cancer survivors: a systematic review with network, dose-response, and Bayesian meta-analyses.

Xi-Nuan Zhang, Zhi-De Liang, Ming-Da Li

Abstract readSystematic ReviewComparative StudyNetwork Meta-Analysis
PubMed Publisher
In one paragraph

Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

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5 · Who and what money

Authors and funding

3 authors.

Xi-Nuan ZhangChengdu Sport University, Chengdu City, Sichuan Province, China.
Zhi-De LiangSchool of Health Sciences and Sports, Macao Polytechnic University, Macao, China.
Ming-Da LiChengdu Sport University, Chengdu City, Sichuan Province, China. 100339@cdsu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundChronic inflammation and immune dysfunction are significant concerns for cancer survivors. Exercise has been proposed as a promising intervention; however, further clarification is needed regarding its effectiveness, optimal modalities, and appropriate exercise prescription.

objectiveThis study aims to explore the effects of different exercise modalities and doses on chronic inflammation and immune function in cancer survivors.

methodsA comprehensive search across five major databases was conducted to identify randomized controlled trials (RCTs) examining exercise interventions on four immune parameters in cancer survivors (leukocyte types, lymphocyte subsets, immune cell functions, soluble inflammatory mediators). The search spanned from the inception of each database until January 2025. The quality of studies was independently evaluated by two reviewers, and network meta-analyses (NMAs) and dose-response analyses were performed using a random-effects model.

resultForty RCTs involving 4048 participants were included. The network meta-analysis revealed that only resistance training (RT) demonstrated a significant effect, ranking the highest (SMD = - 1.42; 95% CrI: - 2.76 to - 0.17). Furthermore, a nonlinear dose-response relationship was observed between exercise interventions and chronic inflammation and immune function. The minimum effective dose was identified as 550 MET-min per week, with an optimal dose of 800 MET-min per week and a maximum safe dose of 960 MET-min per week.

conclusionsExercise is an effective approach to modulating chronic inflammation and immune function in cancer survivors, with an optimal dose of 800 MET-min per week, and RT demonstrating significant effects among different exercise modalities. Future large-scale RCTs are needed to validate the effects of RT across different cancer types and to further refine the dose-response relationship, particularly within the effective dose range.

Indexed as

Cancer SurvivorsExerciseExercise TherapyInflammationNeoplasmsBayes TheoremChronic DiseaseHumansRandomized Controlled Trials as TopicResistance TrainingCancer survivorsChronic inflammationExercise interventionsImmune systemMeta-analysis

Identifiers

PMID41329223

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.