SynthesisSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer2025
Effects of physical exercise in patients undergoing haematopoietic stem cell transplantation: systematic review and meta-analysis.
Synthesis in Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
7 citing papers in PubMed.
- Exercise and nutrition in hematologic malignancies: translational evidence and emerging interventions.Blood neoplasia · 2026Review
- Article
- Article
- Efficacy of exercise interventions in multiple myeloma: a systematic review and meta-analysis.Journal of cancer survivorship : research and practice · 2026Review
- Impact of disease status and general condition on changes in physical function before and after allogeneic hematopoietic stem cell transplantation.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2026Article
- Vitamin D and Hemopoietic Stem Cell Transplantation: Clinical Guidance for GVHD Management and Post-Transplant Outcomes.Cancers · 2026Review
- Home-based, telehealth, and hybrid exercise interventions for adults undergoing or recovering from hematopoietic stem cell transplantation: a systematic review of randomized controlled trials.Frontiers in rehabilitation sciences · 2026Review
Corrections and comments
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Authors and funding
12 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
purposeTo evaluate the effects of physical exercise on key clinical outcomes (such as quality of life (QoL), aerobic capacity, fatigue, and muscle strength) in patients undergoing haematopoietic stem cell transplantation.
methodsPRISMA systematic review and meta-analysis from inception to April 2025. PubMed, Embase, Cochrane Library, Web of Science and Scopus databases were searched for eligible studies. Methodological quality and risk of bias were evaluated with the Pedro scale and the Risk-Of-Bias Tool for randomized trials (ROB2.0) respectively.
resultsAn initial search retrieved 5217 articles. Finally, 20 studies were included in the qualitative synthesis and 7 in the meta-analysis. Exercise showed a small, non-significant effect on QoL (SMD = 0.23; p = 0.072), and a significant moderate effect on functional capacity (SMD = 0.43; p = 0.002). No significant effects were found on fatigue (SMD = - 0.05; p = 0.819) or handgrip strength (SMD = 0.21; p = 0.201), although a large and significant effect was observed for lower limb strength (SMD = 1.48; p < 0.001). Meta-regression analyses indicated that longer intervention duration was significantly associated with greater improvements in fatigue.
conclusionsPhysical exercise improves functional capacity and lower limb strength in transplant patients, while effects on quality of life and fatigue are less consistent. Longer interventions are associated with greater improvements in fatigue. These results support the implementation of prolonged exercise programmes to optimize post-transplant recovery.
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Registered trials
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