ArticleEuropean archives of psychiatry and clinical neuroscience2026
Gender differences and risk factors for suicide attempts in first-episode drug-naïve psychotic versus non-psychotic major depression: a large cross-sectional study.
Article in European archives of psychiatry and clinical neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
Abstract
backgroundThis study aimed to investigate the differential clinical characteristics and distinct risk factors for suicide attempts between patients with psychotic major depression (PMD) and non-psychotic major depression (NPMD).
methodsA cross-sectional analysis was conducted on a cohort of major depressive disorder patients. Comprehensive demographic and clinical data were collected. Assessments included the Hamilton Depression Rating Scale (HAMD), Hamilton Anxiety Rating Scale (HAMA), Positive and Negative Syndrome Scale (PANSS) positive subscale, and Clinical Global Impression-Severity scale (CGI-S). Fasting blood samples were analyzed for thyroid function (TSH, TgAb, TPOAb, FT3, FT4), metabolic parameters (fasting blood glucose, lipid profiles), and other biomarkers.
resultsPatients with PMD demonstrated a more severe clinical profile, including significantly higher HAMD, HAMA, and CGI-S scores, alongside elevated thyroid antibodies (TgAb, TPOAb) compared to the NPMD group. A critical finding was the divergent set of predictors for suicide attempts between the diagnostic subgroups. For the overall MDD cohort and the NPMD subgroup specifically, the severity of anxiety (HAMA) and depression (HAMD) were the primary risk factors. In stark contrast, for patients with PMD, positive psychotic symptoms (PANSS) and elevated TSH levels emerged as the dominant and unique predictors of suicide attempts. ROC analysis confirmed the high discriminatory power of TSH for suicide in PMD (AUC = 0.863).
conclusionsThe path to suicidal behavior differs significantly between PMD and NPMD. Suicide risk in NPMD is primarily driven by the severity of core mood and anxiety symptoms, whereas in PMD, it is predominantly associated with the presence of psychosis and significant HPT axis dysregulation.
Indexed as
Identifiers
41329182What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.