ArticleJournal of feline medicine and surgery2026
Pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks using two injection volumes in adult cats.
Article in Journal of feline medicine and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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6 authors.
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Abstract
ObjectivesThis study described the pharmacokinetics of bupivacaine after bilateral maxillary and caudal inferior alveolar nerve blocks in adult cats under general anaesthesia.MethodsA total of 10 healthy adult cats (mean ± SD weight 4.8 ± 0.8 kg) were included in a randomised, prospective trial. The anaesthetic protocol consisted of acepromazine-methadone-propofol-isoflurane. Each cat randomly received 0.2 (BUPI2) or 0.3 ml (BUPI3) of bupivacaine 0.5% per site (4 and 6 mg per cat, respectively) (n = 5/group). Blood was collected before (time 0) and at 2, 7, 20, 30, 60, 120, 240, 360, 480 and 600 mins after all dental blocks. Plasma concentrations of bupivacaine were analysed using liquid chromatography-tandem mass spectrometry. The pharmacokinetics of bupivacaine were described using a non-compartmental analysis.ResultsMean doses of bupivacaine were significantly different (BUPI2: 0.88 ± 0.14 mg/kg; BUPI3: 1.22 ± 0.21 mg/kg). For BUPI2 and BUPI3, mean maximum bupivacaine plasma concentrations (
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