Evidence map›Paper›PMID 41328657›Full record

ArticleCurrent medical imaging2026

Comparative Analysis of Clinical and MR Imaging Characteristics between Dual-Phenotype Hepatocellular Carcinoma and Conventional Hepatocellular Carcinoma: A Retrospective Study

Xiaoyan Yang, Caiying Wang, Mengsu Zeng, Zhengming Hu, Mingliang Wang

Abstract readComparative Study
In one paragraph

Article in Current medical imaging, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Xiaoyan YangDepartment of Radiology, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen 518000, China.
Caiying WangDepartment of Pathology, Fudan University Zhongshan Hospital, Shanghai 200032, China.
Mengsu ZengDepartment of Radiology, Fudan University Zhongshan Hospital, Shanghai 200032, China.
Zhengming HuDepartment of Ultrasound, Peking University Shenzhen Hospital, Shenzhen 518036, China.
Mingliang WangDepartment of Radiology, Fudan University Zhongshan Hospital, Shanghai 200032, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveThis study aimed to investigate the clinical and MR imaging differences between dual-phenotype hepatocellular carcinoma (DPHCC) and conventional hepatocellular carcinoma (HCC).

methodsA retrospective analysis was conducted on the clinical data and MRI findings of 29 patients with DPHCC and 29 propensity score-matched patients with conventional HCC, confirmed by surgical pathology, from January 2019 to January 2022 at Fudan University Zhongshan Hospital. Clinical characteristics, lesion location, morphology, size, signal intensity, enhancement patterns, vascular invasion, and lymph node metastasis were analyzed for both groups.

resultsBetween the DPHCC group and the HCC group, statistically significant differences were found in cirrhosis, pathological grade, lesion morphology, enhancement patterns, delayed capsular enhancement, and lymph node metastasis. There were no statistically significant differences between the two groups in terms of age, gender, hepatitis B infection, AFP, CA199, microvascular invasion (MVI), capsular invasion, lesion size, location, vascular invasion, ADC values, and T1WI and T2WI signals.

conclusionCompared to HCC, DPHCC has a higher pathological grade, more irregular lesion morphology, and a higher incidence of both fast-in and slow-out and slow-in and slow-out enhancement patterns, as well as higher rates of lymph node metastasis. The findings have provided valuable insights for the accurate diagnosis of DPHCC.

Indexed as

Carcinoma, HepatocellularLiver NeoplasmsMagnetic Resonance ImagingAdultAgedFemaleHumansMaleMiddle AgedPhenotypeRetrospective StudiesADC valuesCirrhosisHepatocellular carcinomaLesion morphologyLiver neoplasmsMagnetic resonance imagingPhenotype.

Identifiers

PMID41328657
PMCPMC13445537

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