Evidence map›Paper›PMID 41328579›Full record

ArticleCirculation. Arrhythmia and electrophysiology2025

Predictors of Response to Cardiac Resynchronization Therapy in Pediatric Patients and Patients With Congenital Heart Disease.

Henry Chubb, Douglas Mah, Maully Shah, Kimberly Y Lin, David Peng, Benjamin W Hale, Lindsay May, Susan Etheridge, William Goodyer, Scott R Ceresnak and 5 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Henry ChubbDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0002-2859-3536
Douglas MahDepartment of Cardiology, Boston Children's Hospital and Department of Pediatrics, Harvard Medical School, MA (D.M.).ORCID 0000-0002-9374-2171
Maully ShahDepartment of Cardiology, Children's Hospital of Philadelphia, PA (M.S., K.Y.L.).ORCID 0000-0002-4743-6915
Kimberly Y LinDepartment of Cardiology, Children's Hospital of Philadelphia, PA (M.S., K.Y.L.).ORCID 0000-0003-1582-9797
David PengDepartment of Cardiology, CS Mott Children's Hospital, University of Michigan, Ann Arbor (D.P., B.W.H.).ORCID 0000-0001-7763-7518
Benjamin W HaleDepartment of Cardiology, CS Mott Children's Hospital, University of Michigan, Ann Arbor (D.P., B.W.H.).ORCID 0000-0002-5613-9808
Lindsay MayDepartment of Cardiology, Primary Children's Hospital, The University of Utah, Salt Lake City (L.M., S.E.).ORCID 0000-0003-0851-7496
Susan EtheridgeDepartment of Cardiology, Primary Children's Hospital, The University of Utah, Salt Lake City (L.M., S.E.).ORCID 0000-0002-2492-422X
William GoodyerDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0002-3252-1180
Scott R CeresnakDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0002-9473-0105
Kara S MotonagaDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0003-4917-1081
David N RosenthalDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0002-6342-2759
Christopher S AlmondDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0001-7136-8337
Doff B McElhinneyDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0001-7242-0934
Anne M DubinDivision of Pediatric Cardiology, Department of Pediatrics (H.C., W.G., S.R.C., K.S.M., D.N.R., C.S.A., D.B.M., A.M.D.), Stanford University, CA.ORCID 0000-0002-3786-1408

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCardiac resynchronization therapy (CRT) is an important therapeutic option in selected pediatric patients and patients with congenital heart disease with reduced systemic ventricular ejection fraction (SVEF). However, the identification of optimal responders is challenging. This study aimed to identify predictors of response to CRT in children and patients with congenital heart disease at 5 large quaternary referral centers.

methodsPatients were aged <21 or had congenital heart disease and had SVEF <45%, symptomatic heart failure, and significant electrical dyssynchrony before CRT. Primary outcome was defined as an ordinal response at 6 or 12 months: (1) improved SVEF (≥5%), (2) unchanged SVEF, and (3) worse SVEF. Secondary outcome utilized a propensity score-matched control cohort. Response to CRT was defined using the longitudinal trajectory of SVEF up to the latest follow-up.

resultsIn total, 167 eligible CRT recipients were identified across the 5 centers; 150 had comprehensive data at 6 or 12 months: 96 (64%) with improved SVEF, 26 (17%) unchanged, and 28 (19%) worsened. Mean increase in SVEF was 11% (interquartile range, 3%-21%). On univariable ordinal regression, lower SVEF (

conclusionsCRT in children and patients with congenital heart disease frequently results in an improvement in SVEF. Those with lower SVEF, conduction delay to the lateral wall of the systemic ventricle, and those with a systemic left ventricle are most likely to respond.

Indexed as

Cardiac Resynchronization TherapyHeart Defects, CongenitalHeart FailureStroke VolumeVentricular Function, LeftAdolescentAge FactorsChildChild, PreschoolFemaleHumansInfantMaleRecovery of FunctionRetrospective StudiesTime Factorsbundle-branch blockcardiac resynchronization therapycongenitalheart defectsheart failurestroke volume

Identifiers

PMID41328579
PMCPMC12711299

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.