Evidence map›Paper›PMID 41328553›Full record

ArticleCirculation. Arrhythmia and electrophysiology2025

Detecting Local Myocardial Spatiotemporal Repolarization Gradients With Clinical Mapping Arrays.

Tasnia Subha, Stéphane Massé, Yusuf Abderrahman, Golnaz Mokhtar-Sasani, Patrick F H Lai, John Asta, Christopher Labos, Abhishek Bhaskaran, Praloy Chakraborty, Vijay S Chauhan and 2 more

Abstract readValidation Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Arrhythmia and electrophysiology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Tasnia SubhaUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0009-0000-2663-5985
Stéphane MasséThe Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, ON (T.S., S.M., Y.A., G.M.-S., P.F.H.L., J.A., K.N.).ORCID 0000-0003-4081-0406
Yusuf AbderrahmanThe Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, ON (T.S., S.M., Y.A., G.M.-S., P.F.H.L., J.A., K.N.).
Golnaz Mokhtar-SasaniThe Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, ON (T.S., S.M., Y.A., G.M.-S., P.F.H.L., J.A., K.N.).
Patrick F H LaiThe Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, ON (T.S., S.M., Y.A., G.M.-S., P.F.H.L., J.A., K.N.).ORCID 0000-0002-8355-7183
John AstaThe Hull Family Cardiac Fibrillation Management Laboratory, University Health Network, Toronto, ON (T.S., S.M., Y.A., G.M.-S., P.F.H.L., J.A., K.N.).
Christopher LabosMcGill University, Montreal, QC, Canada (C.L.).ORCID 0000-0002-6814-3134
Abhishek BhaskaranUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0000-0003-2963-4907
Praloy ChakrabortyUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0000-0002-5054-9136
Vijay S ChauhanUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0000-0001-9264-5073
Paul DorianUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0000-0002-8244-3520
Kumaraswamy NanthakumarUniversity of Toronto (T.S., A.B., P.C., V.S.C., P.D., K.N.).ORCID 0000-0001-8035-5829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundActivation recovery interval (ARI), extracted from unipolar electrograms, serves as a practical surrogate for repolarization during experimental studies in vivo. Far-field signal contamination and low spatial resolution obscure regional repolarization gradients and duration alternans detection using unipolar ARI. We hypothesized that the attenuation of far-field contamination with the principal component-referenced unipole will allow for a more accurate assessment of true local repolarization gradients and spatially assess action potential duration alternans.

methodsUnipolar ARI and the novel method, Repol

resultsFollowing the infusion of antiarrhythmic drugs, the Repol

conclusionsRepol

Indexed as

Action PotentialsArrhythmias, CardiacElectrophysiologic Techniques, CardiacEpicardial MappingHeart Conduction SystemHeart RateVoltage-Sensitive Dye ImagingAnimalsAnti-Arrhythmia AgentsIsolated Heart PreparationLidocainePredictive Value of TestsRabbitsReproducibility of ResultsSwineTime FactorsAnti-Arrhythmia AgentsLidocaineelectrophysiologic studyepicardial mappingintracardiac electrogramlidocainepinacidil

Identifiers

PMID41328553
PMCPMC12711298

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.