Evidence map›Paper›PMID 41328492›Full record

ArticleGut microbes2025

Rebecca L Knoll, Daniel Podlesny, Ingmar Fortmann, Wolfgang Göpel, Michael Zemlin, Susan Lynch, Peer Bork, Stephan Gehring, Christoph Härtel

Erratum issuedAbstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Gut microbes, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Rebecca L KnollDepartment of Pediatrics, University Hospital Mainz, Mainz, Germany.
Daniel PodlesnyMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Ingmar FortmannDepartment of Pediatrics, University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany.
Wolfgang GöpelDepartment of Pediatrics, University Hospital Schleswig-Holstein Campus Lübeck, Lübeck, Germany.
Michael ZemlinDepartment of General Pediatrics and Neonatology, Children's Hospital, Saarland University, Homburg, Germany.
Susan LynchBenioff Center for Microbiome Medicine, Department of Medicine, University of California San Francisco, San Francisco, CA, USA.
Peer BorkMolecular Systems Biology Unit, European Molecular Biology Laboratory, Heidelberg, Germany.
Stephan GehringDepartment of Pediatrics, University Hospital Mainz, Mainz, Germany.
Christoph HärtelDepartment of Pediatrics, University Hospital Würzburg, Würzburg, Germany.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundStaphylococcus (S.) aureus remains a frequent pathogen for neonatal late-onset bloodstream infections (BSIs). The impact of colonization screening on BSI incidence is less understood.

methodsWe assessed the epidemiology of late-onset S. aureus BSI in two independent multicenter cohorts of preterm infants born at < 33 weeks' gestation, the German Neonatal Network (GNN, very low birth weight infants) and PRIMAL (infants with a gestational age 28-32 weeks). In the PRIMAL cohort, we determined S. aureus colonization in fecal samples by culture and shotgun metagenomic sequencing (metaG) during the first year of life. In addition, we integrated publicly available metaG data from preterm infant cohorts born at 23-34 weeks' gestation.

resultsLate-onset S. aureus BSI was noted in 1.5% (336/21491) in preterm infants in the GNN cohort and 0.5% (3/638) in the PRIMAL cohort, respectively. At day 30 of life, 7.6% (42/553) of fecal samples were positive for S. aureus, while available metaG data of corresponding samples revealed S. aureus positivity in 36.6% (159/434). Every 10-fold increase in S. aureus relative abundance (metaG) was associated with a 2.9-fold higher odds of S. aureus detection in blood culture. We also confirmed

conclusionOur study demonstrates that metagenomic quantification of pathobionts such as

Indexed as

BacteremiaStaphylococcal InfectionsStaphylococcus aureusCohort StudiesFecesFemaleGastrointestinal MicrobiomeGermanyGestational AgeHumansIncidenceInfantInfant, NewbornInfant, PrematureInfant, Very Low Birth WeightMalebloodstream infectioncolonizationmetagenomeStaphylococcus aureus

Identifiers

PMID41328492
PMCPMC12674446

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.