Evidence map›Paper›PMID 41328352›Full record

ArticleTheranostics2026

Targeting the ARL4C/RAP1/PI3K-Akt-mTOR signaling loop promotes ARL4C ubiquitination and reverses oxaliplatin resistance in colorectal cancer.

Yang Wang, Zewen Chang, Ziquan Sun, Lu Wang, Jingtao Li, Guodong Li, Yuliuming Wang, Jinning Zhang, Lianjie Ai, Zhongxu Zhang and 2 more

Abstract read
In one paragraph

Article in Theranostics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yang WangColorectal Oncology Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zewen ChangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Ziquan SunDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Lu WangHeilongjiang Province Key Laboratory of Digestive Surgery and Nutrition & Metabolism, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, China.
Jingtao LiDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Guodong LiDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Yuliuming WangColorectal Oncology Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Jinning ZhangColorectal Oncology Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Lianjie AiColorectal Oncology Surgery, The Second Affiliated Hospital of Harbin Medical University, Harbin, China.
Zhongxu ZhangDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Jiaojiao DongDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.
Ming LiuDepartment of General Surgery, The Fourth Affiliated Hospital of Harbin Medical University, Harbin, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

ADP-Ribosylation FactorsColorectal NeoplasmsDrug Resistance, NeoplasmOxaliplatinAnimalsAntineoplastic AgentsApoptosisCell Line, TumorEpithelial-Mesenchymal TransitionFemaleHumansMaleMiceMice, Inbred BALB CMice, NudeMolecular Docking SimulationADP-Ribosylation FactorsAntineoplastic AgentsARL4C protein, humanMTOR protein, humanNaphthoquinonesOxaliplatinPhosphatidylinositol 3-KinasesProto-Oncogene Proteins c-aktTOR Serine-Threonine KinasesARL4Ccolorectal canceroxaliplatinubiquitinationβ-Lapachone

Identifiers

PMID41328352
PMCPMC12665106

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.