Evidence map›Paper›PMID 41328324›Full record

ArticleMedComm2025

Negative Impact of p21-Activated Kinase 4-Mediated AMP-Activated Protein Kinase Inhibition on Sarcopenia in Mice and Humans.

Jiacheng Du, Hwang Chan Yu, Young Jae Moon, Sun-Jung Yoon, Seung-Yong Seo, Byung-Hyun Park, Eun Ju Bae

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in MedComm, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Jiacheng DuDepartment of Biochemistry and Molecular Biology Jeonbuk National University Medical School Jeonju Republic of Korea.
Hwang Chan YuGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea.
Young Jae MoonDepartment of Biochemistry and Molecular Biology Jeonbuk National University Medical School Jeonju Republic of Korea.
Sun-Jung YoonDepartment of Orthopedic Surgery Jeonbuk National University Hospital Jeonju Republic of Korea.
Seung-Yong SeoCollege of Pharmacy Gachon University Incheon Republic of Korea.ORCID https://orcid.org/0000-0002-2672-4707
Byung-Hyun ParkGraduate School of Medical Science and Engineering, Korea Advanced Institute of Science and Technology Daejeon Republic of Korea.ORCID https://orcid.org/0000-0003-3768-4285
Eun Ju BaeSchool of Pharmacy and Institute of New Drug Development Jeonbuk National University Jeonju Republic of Korea.ORCID https://orcid.org/0000-0003-1693-8290

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We recently identified that AMP-activated protein kinase (AMPK) α2 phosphorylation at S491 is mediated by p21-activated kinase 4 (PAK4), leading to muscular and systemic insulin resistance. This study examined how muscle PAK4 deletion affects atrophy in male mice and its link to human sarcopenia. Dexamethasone treatment increased the mRNA and protein levels of PAK4, which was partially the result of glucocorticoid response elements activation in the promoter of the

Indexed as

AMPKmitochondriamuscle atrophyp21‐activated kinase 4proteolysis‐targeting chimera

Identifiers

PMID41328324
PMCPMC12664904

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.