ReviewCureus2025
Evaluating the Effectiveness of Gentamicin-Impregnated Collagen Sponge in the Prevention of Surgical Site Infection in Colorectal Surgery: A Systematic Literature Review and Meta-Analysis.
Review in Cureus, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Surgical site infection (SSI) is a frequent postoperative complication, particularly in colorectal surgeries, which exhibit higher SSI rates than other procedures. The application of Gentamicin-Collagen Implant (GCI) at a local surgical site maximises not only the unique qualities of collagen in enhancing wound healing but also the antibacterial effects of gentamicin. The objective of this study is to determine if SSI is reduced by the use of GCI during colorectal procedures. Included studies were randomised controlled trials (RCTs) comparing GCI use with a defined control in colorectal surgeries. Exclusions comprised non-RCTs, case reports, animal studies, non-colorectal surgery comparisons, and studies lacking relevant endpoints. Literature searches were conducted in January 2025 using the SCOPUS, PubMed, Embase, and Cochrane Library medical databases. Risk of bias was assessed with the Rob2 tool (Cochrane Collaboration, Oxford, UK), and a meta-analysis was conducted using Review Manager (Cochrane Collaboration). Endpoints included incisional SSI, primary wound healing, and disease recurrence. Fourteen RCTs with 2,233 patients (1,114 with and 1,119 without GCI) were analysed. GCI significantly lowered overall SSI incidence (RR = 0.54; CI = 0.35-0.85; p = 0.007) and specifically in rectal surgeries (RR = 0.56; CI = 0.39-0.81; p = 0.002). No significant effect was observed in pilonidal disease surgeries (RR = 0.34; CI = 0.09-1.23; p = 0.10) or its recurrence (RR = 0.62; CI = 0.09-4.57; p = 0.64). GCI effectively reduces SSI in rectal surgeries but not in pilonidal disease operations. Routine GCI may reduce SSI in rectal surgery.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.