Evidence map›Paper›PMID 41328041›Full record

ArticleJMIR public health and surveillance2025

Long-Term Ambient Air Pollution Exposure and the Risk of Cardiovascular and Cerebrovascular Diseases in Rural Chinese Populations: 10-Year Follow-Up of a Multicenter Prospective Cohort Study.

Yaqi Zhao, Xuefang Cao, Jiang Du, Aiwei He, Jun Liang, Weitao Duan, Yuanzhi Di, Yijun He, Boxuan Feng, Linyu Shen and 16 more

Abstract readMulticenter Study
In one paragraph

Article in JMIR public health and surveillance, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

26 authors.

Yaqi Zhao *NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0004-7693-5248
Xuefang Cao *NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0000-0001-9871-3065
Jiang Du *NHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0009-9507-040X
Aiwei HeTuberculosis Prevention and Control Department, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China.ORCID 0009-0003-2088-5141
Jun LiangTuberculosis Prevention and Control Department, Hunan Provincial Institute of Tuberculosis Prevention and Control, Changsha, Human, China.ORCID 0009-0004-6370-4571
Weitao DuanTuberculosis Prevention and Control Department, Zhongmu County Center for Disease Control and Prevention, Zhongmu, China.ORCID 0009-0008-0115-733X
Yuanzhi DiNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0003-8543-0148
Yijun HeNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0000-0002-0291-3749
Boxuan FengNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0001-4031-6857
Linyu ShenNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0000-2885-8891
Juanjuan HuangNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0000-0003-4124-8144
Zihan LiNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0005-1867-6839
Jianguo LiangNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0000-0003-1290-2581
Hongzhi LiZhengzhou Sixth People's Hospital, Zhengzhou, Henan, China.ORCID 0009-0009-9176-6266
Zisen LiuTuberculosis Prevention and Control Department, Zhongmu County Center for Disease Control and Prevention, Zhongmu, China.ORCID 0009-0002-1646-8591
Fang LiuTuberculosis Prevention and Control Department, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China.ORCID 0009-0003-3888-9116
Shumin YangTuberculosis Prevention and Control Department, Gansu Provincial Center for Disease Control and Prevention, Lanzhou, China.ORCID 0009-0006-6116-1803
Zuhui XuTuberculosis Prevention and Control Department, Hunan Provincial Institute of Tuberculosis Prevention and Control, Changsha, Human, China.ORCID 0009-0007-4972-4201
Bin ZhangTuberculosis Prevention and Control Department, Zhongmu County Center for Disease Control and Prevention, Zhongmu, China.ORCID 0009-0004-3102-6577
Jiaoxia YanTuberculosis Prevention and Control Department, Zhongmu County Center for Disease Control and Prevention, Zhongmu, China.ORCID 0009-0009-8186-3361
Yanchun LiangTuberculosis Prevention and Control Department, Longxi County Center for Disease Control and Prevention, Longxi, China.ORCID 0009-0009-3069-5660
Rong LiuTuberculosis Prevention and Control Department, Xiangtan County Center for Disease Control and Prevention, Xiangtan, China.ORCID 0009-0008-2084-4880
Fei ShenZhengzhou Sixth People's Hospital, Zhengzhou, Henan, China.ORCID 0009-0004-4398-4174
Qi JinNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0007-8825-3609
Henan XinNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0009-0008-5008-0412
Lei GaoNHC Key Laboratory of Systems Biology of Pathogens, National Institute of Pathogen Biology, and Center for Tuberculosis Research, Chinese Academy of Medical Sciences & Peking Union Medical College, No.16 Tianrong Street, Beijing, 102629, China, 86 13311185615.ORCID 0000-0002-9957-4527

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Long-term follow-up studies investigating the relationship between ambient air pollution and cardiovascular and cerebrovascular diseases (CVD) in rural Chinese populations remain limited. Objective: This study aimed to investigate the impact of prolonged exposure to particulate matter with aerodynamic diameter ≤2.5 μm (PM2.5) on CVD in rural areas of China. Methods: On the basis of a multicenter population-based prospective study, adult rural residents (aged ≥15 y) from 3 study sites (ie, Xiangtan, Hunan Province; Longxi, Gansu Province; and Zhongmu, Henan Province) with different PM2.5 exposure levels were tracked for the incidence of CVD events between 2013 and 2023. The relationship was assessed by applying the Cox proportional hazards model and a trend test. Results: A total of 15,502 participants were included in the study. During the 10-year follow-up period, for every 1 μg/m3 increase in PM2.5, the risks of CVD, ischemic stroke, coronary heart disease, acute coronary syndrome, and intracerebral hemorrhage increased by 5% (hazard ratio [HR] 1.05, 95% CI 1.04-1.06), 7% (HR 1.07, 95% CI 1.06-1.08), 8% (HR 1.08, 95% CI 1.07-1.09), 9% (HR 1.09, 95% CI 1.06-1.11), and 10% (HR 1.10, 95% CI 1.07-1.14), respectively. Furthermore, the risk in the high exposure group (Q4) was found to be significantly higher than that in the low exposure group (Q1; P for trend <.001). The subgroup analysis indicated that the risk of CVD was higher among older people compared to individuals aged <60 years, and the interaction effect was statistically significant (interaction P value=.03). Conclusions: Our results indicate that long-term exposure to PM2.5 significantly increases the risk of CVD in rural areas of China and shows regional differences. This finding may deepen our understanding of the potential public health risks associated with PM2.5 exposure and emphasize the crucial role of environmental governance in promoting public health outcomes.

Indexed as

Air PollutionCardiovascular DiseasesCerebrovascular DisordersEnvironmental ExposureRural PopulationAdolescentAdultAgedChinaEast Asian PeopleFemaleFollow-Up StudiesHumansMaleMiddle AgedParticulate MatterParticulate Matterair pollutioncardiovascular and cerebrovascular diseasesCox proportional hazards modelparticulate matterprospective study

Identifiers

PMID41328041
PMCPMC12669913

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.