ArticleInfection & chemotherapy2025
Impact of COVID-19 on Invasive Pneumococcal Disease: A Comparative Analysis of Clinical Features and Antibiotic Resistance across Pandemic Periods.
Article in Infection & chemotherapy, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
10 authors.
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Abstract
backgroundThe coronavirus disease 2019 pandemic and associated infection control measures (lockdowns, masking) dramatically altered infectious disease epidemiology, including reduced invasive pneumococcal disease (IPD) incidence. This study aimed to assess the pandemic effects on IPD clinical features, outcomes, and antibiotic resistance in children. MATERIALS AND
methodsThis study included pediatric patients (1 month to 18 years) diagnosed with IPD, comparing two distinct periods: the pre-pandemic era (March 2014-February 2020) and pandemic/post-pandemic era (March 2020-March 2024). Clinical characteristics and antibiotic resistance patterns of IPD patients were compared between the pre-pandemic and pandemic/post-pandemic periods.
resultsAmong 61 cases (27 pre-pandemic, 34 pandemic/post-pandemic), age distribution remained similar (median 46
conclusionIPD remains a significant pediatric health concern. IPD continues to disproportionately affect children under five years of age, with no significant pandemic-related changes in age distribution, disease manifestations, or clinical outcomes. The concerning rise in resistance to first-line antibiotics during the pandemic underscores the urgent need for robust antimicrobial stewardship programs.
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