Evidence map›Paper›PMID 41327890›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026

Mucin-Inspired Filamentous Sulfated Copolymers Effectively Inhibit Human Respiratory Syncytial Virus (hRSV) Infectivity.

Raju Bej, Enyu Xie, Kai Ludwig, Robert F Schmidt, Yannic Kerkhoff, Robert Dalgliesh, Nilanjan Paul, Michael Gradzielski, Andreas Herrmann, Christian Sieben and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Raju BejJyoti and Bhupat Mehta School of Health Sciences and Technology, Indian Institute of Technology Guwahati, Guwahati, 781039, India.ORCID https://orcid.org/0000-0002-8453-6966
Enyu XieNanoscale Infection Biology Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.ORCID https://orcid.org/0000-0001-7611-0415
Kai LudwigInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Robert F SchmidtStranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, 10623, Berlin, Germany.
Yannic KerkhoffInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Robert DalglieshISIS Pulsed Neutron and Muon Source, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Oxford, Didcot, OX11 0QX, UK.ORCID https://orcid.org/0000-0002-6814-679X
Nilanjan PaulJyoti and Bhupat Mehta School of Health Sciences and Technology, Indian Institute of Technology Guwahati, Guwahati, 781039, India.
Michael GradzielskiStranski-Laboratorium für Physikalische und Theoretische Chemie, Institut für Chemie, Technische Universität Berlin, 10623, Berlin, Germany.ORCID https://orcid.org/0000-0002-7262-7115
Andreas HerrmannInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.
Christian SiebenNanoscale Infection Biology Group, Helmholtz Centre for Infection Research, Inhoffenstraße 7, 38124, Braunschweig, Germany.ORCID https://orcid.org/0000-0002-2836-2623
Rainer HaagInstitut für Chemie und Biochemie, Freie Universität Berlin, Takustraße 3, 14195, Berlin, Germany.ORCID https://orcid.org/0000-0003-3840-162X

Funding

China Scholarship Council 202106990020Deutsche Forschungsgemeinschaft Project ID 431232613 - SFB 1449Helmholtz-Gemeinschaft VH-NG-1526IIT Guwahati SHSTSUGIITG1492RAJU001
6 · The paper itself

Abstract

Virucidal compounds capable of binding to and disrupting viruses represent a promising avenue for antiviral applications. In this study, the development of high molecular weight (≈300 kDa) dendronized polyglycerol-based mucin-inspired amphiphilic statistical copolymers (MIACPs) is reported using the RAFT polymerization technique. These copolymers comprise ≈30% repeat units containing aliphatic C11 carbon chains with terminal carboxylate (MIACP-1) and alkyl (MIACP-2) functionalities, while the remaining ≈70% of the repeat units consist of dendronized polyglycerol sulfates. Structural characterization using cryo-electron microscopy (cryo-EM) and small-angle neutron scattering (SANS) reveals that MIACPs form single-chain filamentous structures, similar to natural porcine gastric mucin (PGM). These biocompatible MIACPs exhibit strong, sulfate-dependent inhibition of human respiratory syncytial virus (hRSV), with exceptionally low IC

Indexed as

Antiviral AgentsMucinsPolymersRespiratory Syncytial Virus, HumanSulfatesAnimalsCryoelectron MicroscopyGlycerolHumansSwineAntiviral AgentsGlycerolMucinspolyglycerolPolymersSulfatesbiocompatiblecryo‐EMfilamentous structurehRSV inhibition and virucidalitymucin‐inspired copolymerRAFT polymerizationsmall angle neutron scattering (SANS)

Identifiers

PMID41327890
PMCPMC12904038

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.