Evidence map›Paper›PMID 41327829›Full record

SynthesisAnnals of medicine2025

Adjuvant roles of interleukin-7 in enhancing T cell recovery during antiretroviral therapy for individuals with HIV: a systematic review and meta-analysis.

Bixin Deng, Xia Qiu, Ruixi Zhou, Tiechao Ruan, Wenting Lu, Dezhi Mu

Abstract readMeta-AnalysisSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Annals of medicine, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Bixin DengDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Xia QiuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Ruixi ZhouDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Tiechao RuanDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.
Wenting LuIntegrated Care Management Center, West China Hospital, Sichuan University, Chengdu, China.
Dezhi MuDepartment of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundT cell suppression has been observed in individuals with human immunodeficiency virus (HIV) undergoing antiretroviral therapy (ART). This study aimed to evaluate the effect of interleukin (IL)-7 on T cell count and HIV DNA load in individuals with HIV receiving long-term ART.

methodsWe screened English-language articles on PubMed, Embase, Cochrane, and Web of Science from inception up to April 7, 2023. The included articles were assessed using the Cochrane risk-of-bias assessment tool. A meta-analysis of CD4

resultsEight articles were included in our study. CD4

conclusionOur analysis revealed that IL-7 can induce an increase in CD4

Indexed as

Anti-HIV AgentsAnti-Retroviral AgentsHIV InfectionsInterleukin-7Antiretroviral Therapy, Highly ActiveCD4 Lymphocyte CountCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesDNA, ViralHIV-1HumansViral LoadAnti-HIV AgentsAnti-Retroviral AgentsDNA, ViralIL7 protein, humanInterleukin-7CD4+ T cell countsCD8+ T cell countsHIVHIV-DNA loadIL-7

Identifiers

PMID41327829
PMCPMC12671416

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.