Evidence map›Paper›PMID 41327590›Full record

ArticleBJPsych open2025

The effect of age on the clinical presentation and treatment of women with psychosis: secondary analysis of the IMPaCT Randomised Clinical Trial.

Maria Antonietta Nettis, Khalida Ismail, Robin M Murray, Aikaterini Dima, Kathryn Greenwood, Zerrin Atakan, Shubulade Smith, Fiona Gaughran

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BJPsych open, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria Antonietta Nettishttps://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-5401-8391
Khalida IsmailDepartment of Psychological Medicine, Institute of Psychiatry, Psychology and Neurosciences, King's College London, London, UK.
Robin M Murrayhttps://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.
Aikaterini DimaInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.ORCID https://orcid.org/0000-0002-6371-775X
Kathryn GreenwoodSussex Partnership NHS Foundation Trust and School of Psychology, University of Sussex, Brighton, UK.ORCID https://orcid.org/0000-0001-7899-8980
Zerrin AtakanInstitute of Psychiatry, Psychology and Neuroscience, King's College London, London, UK.
Shubulade Smithhttps://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0002-3797-6985
Fiona Gaughranhttps://ror.org/015803449South London and Maudsley NHS Foundation Trust, London, UK.ORCID https://orcid.org/0000-0001-7414-5569

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundAccording to existing evidence, during menopause transition, women with psychosis may present with exacerbated psychiatric symptoms, due to age-related hormonal changes.

aimsWe aimed to (a) replicate this evidence, using age as a proxy for peri/menopausal status; (b) investigate how clinical presentation is affected by concomitant factors, including hyperprolactinaemia, dose and metabolism of prescribed antipsychotics using cross-sectional and longitudinal analyses.

methodSecondary analysis on 174 women aged 18-65, from the IMPaCT (Improving physical health and reducing substance use in psychosis) randomised controlled trial. We compared women aged below (

resultsWomen aged above 40 showed higher baseline PANSS total score (mean ± s.d. = 53.4 ± 14.1

conclusionsWomen aged above 40 showed worse psychotic symptoms than younger women. This difference seems diagnosis-specific and may be influenced by antipsychotics metabolism. Further longitudinal data are needed considering the menopause transition.

Indexed as

agemenopauseprolactinpsychosisWomen

Identifiers

PMID41327590
PMCPMC12724110

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.