Evidence map›Paper›PMID 41327528›Full record

ArticleTherapeutic drug monitoring2026

Deadly Combination of Formic and Sulfuric Acid: 2 Cases of Carbon Monoxide Intoxication.

Corine Bethlehem, Nanda M van Dam, Linda G W Franken, Dieuwertje van den Bogart, Marika Wind, Birgit C P Koch

Abstract readCase Reports
In one paragraph

Article in Therapeutic drug monitoring, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Corine BethlehemErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands.
Nanda M van DamErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands.
Linda G W FrankenDepartment of Hospital Pharmacology and Clinical Pharmacology, Amsterdam UMC, Location University of Amsterdam, Amsterdam, the Netherlands.
Dieuwertje van den BogartForensic Physicians Rotterdam (FARR), the Netherlands; and.
Marika WindPublic Health Region Service (GGD) Region Utrecht, the Netherlands.
Birgit C P KochErasmus MC, University Medical Center Rotterdam, Department of Hospital Pharmacy, the Netherlands.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundCarbon monoxide (CO) poisoning is associated with high morbidity and mortality rates. Although accidental inhalation is the most common cause, suicide through CO from a mixture of formic and sulfuric acids is extremely rare and poses unique risks to first responders. CASE PRESENTATIONS: Two male individuals died in their vehicles after mixing formic and sulfuric acid to generate CO. Both cases showed characteristic cherry-red or pink livor mortis and high postmortem carboxyhemoglobin levels (73% and 85%, respectively). In both scenes, labeled acid containers and enclosed spaces were present, with 1 case noting an unusual odor.

conclusionsChemically induced CO poisoning, although rare, requires heightened awareness among first responders because of the danger of undetected exposure. Key indicators include unusual livor mortis, enclosed or taped-off spaces, chemical smells, and the presence of acid containers. Postmortem toxicology is crucial for confirming a diagnosis and understanding the cause of death.

Indexed as

Carbon Monoxide PoisoningFormatesSulfuric AcidsAdultCarboxyhemoglobinFatal OutcomeHumansMaleMiddle AgedSuicide, CompletedCarboxyhemoglobinFormatesformic acidsulfuric acidSulfuric Acidscarbon monoxideformic acidintoxicationsulfuric acid

Identifiers

PMID41327528
PMCPMC12978720

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.