ArticleJournal of cachexia, sarcopenia and muscle2025
A Simplified Frailty Measure Improves Risk Stratification in Patients Undergoing Percutaneous Mitral Valve Repair.
Article in Journal of cachexia, sarcopenia and muscle, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Simplified Frailty Measure Improves Risk Stratification in Patients Undergoing Percutaneous Mitral Valve Repair.Journal of cachexia, sarcopenia and muscle · 2025Article
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Authors and funding
10 authors.
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No grant is acknowledged in the PubMed record.
Abstract
objectiveThe aim of this study was to examine frailty measures for risk prediction in patients undergoing percutaneous mitral valve repair (PMVR).
backgroundPerformance of current risk prediction models based on organ morbidity is only moderate.
methodsThe frailty domains exhaustion, slowness, inactivity, weakness, and unintentional weight loss were prospectively assessed in patients undergoing PMVR. The association with mortality and heart failure hospitalization (HFH) during a median follow-up of 506 days was examined and relevant domains were assessed for additive predictive performance over the MitraScore.
resultsFive hundred twenty-four patients were included in the study (mean age [SD]: 77 (9) years, 54.6% male). The risk of mortality and mortality/HFH were significantly increased in patients with exhaustion (hazard ratio: 2.24 [95% CI: 1.63-3.08]/1.83 [1.21-2.77]), slowness (2.74 [1.75-4.30]/1.92 [1.34-2.75]), inactivity (1.96 [1.26-3.05]/1.61 [1.12-2.31]) and weakness (1.83 [1.12-2.96]/1.34 [0.92-1.95]), but not in patients with weight loss (1.24 [0.80-1.92]/1.12 [0.78-1.61]). A simplified frailty (S-frailty) measure derived from the domains exhaustion and slowness was associated with mortality (4.45 [2.42-8.19]) and mortality/HFH (2.60 [1.64-4.13]) independently of clinical risk factors and the MitraScore, respectively. Prediction of mortality by the MitraScore was significantly improved when adding S-frailty (Harrell's C 0.645 vs. 0.700, p = 0.002). Classification of 1-year mortality risk by the MitraScore improved when adding S-frailty (net reclassification index 0.21, p = 0.012 and integrated discrimination index 0.07, p < 0.001).
conclusionsA simplified frailty measure comprising self-reported exhaustion and gait speed significantly improved risk prediction in patients undergoing PMVR. Assessment of frailty measures should be part of the decision-making process and multiparametric risk scores in patients with severe mitral regurgitation.
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