Evidence map›Paper›PMID 41327509›Full record

ArticleRenal failure2025

Triglyceride-glucose index and triglyceride-to-high-density lipoprotein cholesterol ratio as novel predictors of acute kidney injury: an analysis of the UK biobank.

Fangfang Zhou, Yuanyuan Wang, Youjun Xu, Lailiang Wang, Jinxia Ge, Qun Luo, Hongpeng Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Renal failure, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

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5 · Who and what money

Authors and funding

7 authors.

Fangfang ZhouDepartment of Nephrology, Ningbo NO.2 Hospital, Ningbo, Zhejiang, China.
Yuanyuan WangSchool of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.
Youjun XuDepartment of Nephrology, Ningbo NO.2 Hospital, Ningbo, Zhejiang, China.
Lailiang WangDepartment of Nephrology, Ningbo NO.2 Hospital, Ningbo, Zhejiang, China.ORCID 0000-0002-4754-9602
Jinxia GeDepartment of Nephrology, Ningbo NO.2 Hospital, Ningbo, Zhejiang, China.
Qun LuoDepartment of Nephrology, Ningbo NO.2 Hospital, Ningbo, Zhejiang, China.
Hongpeng SunSchool of Public Health, Suzhou Medical College of Soochow University, Suzhou, Jiangsu, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The triglyceride-glucose (TyG) index and triglyceride to high-density lipoprotein cholesterol (TG/HDL-C) ratio are recognized markers of insulin resistance, but their associations with acute kidney injury (AKI) risk remain understudied in large populations. Using data from the UK Biobank (UKB) and the UK Biobank Pharma Proteomics Project (UKB-PPP), this study investigated whether these indices are linked to AKI risk. A total of 427,659 participants from the UKB were retrospectively analyzed and stratified into quintiles based on TyG index or TG/HDL-C ratio. Among them, 22,447 (5.25%) developed AKI. Kaplan-Meier analysis revealed a progressive increase in AKI risk across rising quintiles of both indices (

Indexed as

Acute Kidney InjuryBlood GlucoseCholesterol, HDLTriglyceridesAdultAgedBiological Specimen BanksBiomarkersFemaleHumansInsulin ResistanceKaplan-Meier EstimateMaleMiddle AgedRetrospective StudiesRisk FactorsBiomarkersBlood GlucoseCholesterol, HDLTriglyceridesAcute kidney injuryinsulin resistancemediating proteintriglyceride-glucose indextriglyceride-to-high-density lipoprotein cholesterol ratio

Identifiers

PMID41327509
PMCPMC12671427

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.