Evidence map›Paper›PMID 41327490›Full record

ReviewEye and vision (London, England)2025

The physiological functions of OPN5m.

Jiali Ma, Sheikh Mizanur Rahaman, Yu Ohmura, Akihiro Yamanaka

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Eye and vision (London, England), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Acute Ocular Effects of Violet and Red Light Exposure in Young Adults.Ophthalmic & physiological optics : the journal of the British College of Ophthalmic Opticians (Optometrists) · 2026
    Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Jiali Ma *Beijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China.
Sheikh Mizanur Rahaman *Department of Neural Regulation, Nagoya University Graduate School of Medicine, Nagoya, 466-8550, Japan.
Yu OhmuraBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China. yuohmura@cibr.ac.cn.
Akihiro YamanakaBeijing Institute for Brain Research, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing, 102206, China. yamank@cibr.ac.cn.ORCID http://orcid.org/0000-0001-6099-7306

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Opsin 5 (OPN5), also known as neuropsin, is a violet/ultraviolet (UV) light-sensitive G protein-coupled receptor (GPCR) conserved across vertebrates. Most mammals possess a single OPN5 gene (OPN5m), whereas non-mammalian species also express OPN5L1 and OPN5L2 with distinct molecular properties. Mammalian OPN5 (OPN5m) functions as a non-visual photopigment, expressed in diverse extra-retinal tissues including the skin, testis, and brain. Recent studies reveal species-specific signaling: human OPN5m preferentially activates Gq-mediated Ca

Indexed as

Circadian photoentrainmentG protein-coupled receptorHypothalamusLight-dependent signalingMyopia suppressionNon-visual photoreceptionOPN5Retinal ganglion cellsThermoregulationViolet light

Identifiers

PMID41327490
PMCPMC12670784

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.