ArticleActa neuropathologica communications2025
Brain-derived neurotrophic factor supports pericyte and vascular homeostasis in the aging brain.
Article in Acta neuropathologica communications, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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2 citing papers in PubMed.
- Schwann Cell Mapping and Characterization in Bone of Different Embryonic Origins.bioRxiv : the preprint server for biology · 2026Article
- DGAT1 Drives Racially Divergent Fibroblast Activation via ERK1/2-Dependent Tumorigenic Signaling in Prostate Cancer.Cancer research communications · 2026Article
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10 authors.
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Abstract
Microvascular circulation in the brain is often impaired in connection with the loss of pericytes in old age. The neurotrophic factor BDNF also decreases in the aging brain. We hypothesized that BDNF regulates the homeostasis of cerebral pericytes and microvasculature. We used differently aged C57BL/6J mice, and C57BL/6 mice with conditional knockout of Bdnf gene. Collagen IV-positive microvessels and PDGFRβ-positive pericytes in the brain were counted after immunological staining. Pericytes were also quantified by Western blot of PDGFRβ and CD13 in isolated cerebral microvessels and flow cytometric analysis of brain cells. The level of BDNF and TrkB phosphorylation was determined in brain homogenates. To demonstrate the direct effect of BDNF on pericytes, TrkB and pericytes were co-stained in brain tissue, single-cell sequencing and transcriptomic analysis were used to identify and characterize Ntrk2-expressing pericytes, and TrkB was detected in the pericyte cell line by Western blot. Cultured pericytes were further treated with recombinant BDNF in the presence and absence of an Akt inhibitor and examined for PDGFRβ expression. The length and branching of microvessels and pericytes decreased in conjunction with the reduction in mature BDNF in aging brains. Deficiency of BDNF in neurons or astrocytes was sufficient to reduce cerebral microvessels, PDGFRβ concentrations and Akt and Erk1/2 phosphorylation in isolated blood vessels. A subset of pericytes in the brain and cultured pericytes expressed TrkB. BDNF treatment increased PDGFRβ expression along with Akt and Erk1/2 phosphorylation in cultured cells. The effect of BDNF on PDGFRβ expression was abolished by treatment with Akt inhibitor. Therefore, BDNF induces the expression of PDGFRβ by activating Akt signaling in pericytes, promoting the homeostasis of pericytes and microvasculature in the aging brain. Our study identified a BDNF-mediated mechanism that regulates microvascular integrity in the aged brain.
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