Evidence map›Paper›PMID 41327359›Full record

ArticleMolecular horticulture2025

Strawberry cryptochrome FvCRY1 and FvCRY2 transcriptionally regulate anthocyanin biosynthesis and sugar metabolism.

Lianxi Zhang, Anqi Lin, Xiaoyi Bi, Yuxuan Zhu, Lin Ye, Jiwen Lian, Pengbo Xu, Hongli Lian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular horticulture, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Lianxi Zhang *Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Anqi Lin *Shanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Xiaoyi BiShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Yuxuan ZhuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Lin YeShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Jiwen LianShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China.
Pengbo XuShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. xpb2005@sjtu.edu.cn.ORCID http://orcid.org/0000-0001-9364-4240
Hongli LianShanghai Collaborative Innovation Center of Agri-Seeds, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China. hllian@sjtu.edu.cn.

Funding

National Natural Science Foundation of China 32172536National Natural Science Foundation of China 32472704Natural Science Foundation of Shanghai 23ZR1434300Shanghai Agricultural Science and Technology Innovation Program 2023-02-08-00-12-F04600Shanghai Agricultural Science and Technology Innovation Program 2024-02-08-00-12-F00013Startup Fund for Young Faculty at SJTU 23X010502175
6 · The paper itself

Abstract

Anthocyanin pigmentation and soluble sugar content are important factors affecting the quality of strawberry fruits, and their accumulation processes are profoundly influenced by light signals. However, the molecular mechanism through which light regulates this process remains to be fully elucidated. Here, we identified two blue light receptors, FvCRY1 and FvCRY2, from woodland strawberry. Functional complementation in Arabidopsis cryptochrome mutant confirmed their photoperceptor roles. Stable overexpression of FvCRYs in cultivated strawberry (Fragaria × ananassa 'Ningyu') significantly enhanced anthocyanin accumulation and soluble sugar content, concomitant with upregulation of key biosynthetic genes. Strikingly, yeast one-hybrid and dual-luciferase assays revealed FvCRYs possess intrinsic transcriptional activation domains that directly bind E-box cis-elements in promoters of anthocyanin synthesis gene FvCHS2, FvDFR2, FvCHI, and sugar metabolism-related genes FvSFP9 and FvINV. This DNA-binding capacity is potentiated by blue light, enabling transcriptional expression of anthocyanin synthesis and sugar metabolism genes. Our findings unveil a non-canonical cryptochrome signaling mechanism involving direct receptor-promoter interaction, redefining our understanding of photoreceptor-mediated frui quality regulation.

Indexed as

AnthocyaninCryptochromeStrawberrySugarTranscriptional regulation

Identifiers

PMID41327359
PMCPMC12670867

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.