Evidence map›Paper›PMID 41327346›Full record

ArticleWorld journal of surgical oncology2025

Independent predictors and ultrasound-based risk stratification for follicular thyroid tumors: a multicenter retrospective study.

Chi Ma, Minying Zhong, Deli Chen, Jieyi Ye, Sixin Cheng, Jingzi Fu, Weijun Huang, Chaojiong Zhen, Yingjia Li

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in World journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

9 authors.

Chi Ma *Guangdong Medical University, Zhanjiang, Guangdong Province, 524023, China.
Minying Zhong *The First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong Province, 528000, China.
Deli ChenThe First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong Province, 528000, China.
Jieyi YeThe First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong Province, 528000, China.
Sixin ChengGuangdong Medical University, Zhanjiang, Guangdong Province, 524023, China.
Jingzi FuGuangdong Medical University, Zhanjiang, Guangdong Province, 524023, China.
Weijun HuangThe First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong Province, 528000, China.
Chaojiong ZhenThe First People's Hospital of Foshan (Foshan Hospital Affiliated to Southern University of Science and Technology), School of Medicine, Southern University of Science and Technology, Foshan, Guangdong Province, 528000, China. cjzhen715@163.com.
Yingjia LiDepartment of Medicine Ultrasonics, Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, 510515, China. lyjia@smu.edu.cn.

Funding

Basic and Applied Basic Research Foundation of Guangdong Province,China 2023A1515220135
6 · The paper itself

Abstract

objectiveThis retrospective study aimed to investigate the ultrasound characteristics of follicular thyroid adenoma (FTA) and follicular thyroid carcinoma (FTC) and to evaluate the diagnostic efficacy of Follicular Thyroid Imaging Reporting and Data System (F-TIRADS), American College of Radiology (ACR)-TIRADS, and Chinese (C)-TIRADS in differentiating FTC from FTA. MATERIALS AND

methodsThis study included 399 patients with pathologically confirmed FTC or FTA who underwent preoperative thyroid ultrasonography. The ultrasound characteristics and the scores of F-TIRADS, ACR-TIRADS, and C-TIRADS were evaluated. Univariate analysis and multivariate logistic regression were conducted to identify independent predictors of FTC. Sensitivity, specificity, accuracy, positive predictive value (PPV), negative predictive value (NPV), area under the curve (AUC), and p-values were compared.

resultsMultivariate logistic regression analysis identified unclear margins, spiculated margins, halo contour, uneven halo thickness, trabecular formation, and multifocal tumors as independent predictors of FTC (odds ratio [OR] = 4.74, 82.68, 0.07, 5.82, 3.26, and 82.09, respectively). The AUC values for the F-TIRADS, ACR-TIRADS, and C-TIRADS were 0.825 (95% confidence interval [CI]: 0.763-0.887), 0.713 (95% CI: 0.645-0.782), and 0.756 (95% CI: 0.685-0.827), respectively.

conclusionsUltrasound is valuable in differentiating FTC from FTA, with the F-TIRADS exhibiting superior diagnostic performance compared with those of the ACR-TIRADS and C-TIRADS.

Indexed as

Adenocarcinoma, FollicularAdenomaThyroid NeoplasmsAdultAgedDiagnosis, DifferentialFemaleFollow-Up StudiesHumansMaleMiddle AgedPrognosisRetrospective StudiesRisk AssessmentUltrasonographyYoung AdultFollicular thyroid adenomaFollicular thyroid carcinomaF-TIRADSUltrasonography

Identifiers

PMID41327346
PMCPMC12798104

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.