ArticleJournal of orthopaedic surgery and research2025
Conservative treatment using blood flow restriction and brace in individuals with complete anterior cruciate ligament rupture: protocol for a randomised clinical trial.
Article in Journal of orthopaedic surgery and research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06727344 (Comparison of Conservative Treatment With Blood Flow Restriction With Standard Management in Total ACL Rupture. "Randomized Clinical Trial"), which is not on this map. Not yet cited in PubMed.
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Comparison of Conservative Treatment With Blood Flow Restriction With Standard Management in Total ACL Rupture. "Randomized Clinical Trial"
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4 authors.
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Abstract
backgroundInadequate long-term outcomes are common following both surgical and non-surgical management of anterior cruciate ligament (ACL) rupture. Emerging evidence suggests that a bracing protocol may facilitate ligamentous healing; however, a period of immobilisation can induce muscle atrophy. This study aims to investigate the potential benefits of adding blood flow restriction (BFR) training to the conservative treatment of ACL rehabilitation.
methodsThis is a double-blinded, two-arm randomised clinical trial. Participants in the intervention group will follow an exercise protocol using BFR training, while participants in the control group will follow the same protocol with sham-BFR. Both groups will follow the same bracing protocol. Individuals aged between 18 and 40 years with an acute or subacute complete ACL tear confirmed by imaging will be eligible to participate. DISCUSSION: Emerging evidence suggests that a conservative period of joint immobilisation, in which positioning the knee reduces the distance between the two torn ligament ends, may promote ACL healing after a complete rupture. However, the use of a brace can result in muscle atrophy. BFR exercises may play an important role during this period of immobilisation and restricted movement. Positive results of exercise under BFR, in combination with a brace, could serve as an alternative treatment for participants with acute or subacute complete ACL tears, potentially reducing recovery time or even avoiding surgery. Trial registration This protocol was approved by the Cyprus National Bioethics Committee (ΕΕΒΚ/ΕΠ/2024/70) and registered on ClinicalTrials.gov (Registration number: NCT06727344).
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