Evidence map›Paper›PMID 41327332›Full record

ArticleJournal of nanobiotechnology2025

Hypoxia-activated paclitaxel prodrugs enable PD-L1 degradation to potentiate cancer chemo-immunotherapy.

Shiyu Zhou, Qiang Zhang, Hui Han, Guang Chen, Peisong Wang, Shuai Xue, Qing Pei, Zhigang Xie, Xianying Meng

Abstract read
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Shiyu ZhouDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Qiang ZhangDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Hui HanDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Guang ChenDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Peisong WangDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Shuai XueDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China.
Qing PeiState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China. peiqing@ciac.ac.cn.
Zhigang XieState Key Laboratory of Polymer Science and Technology, Changchun Institute of Applied Chemistry, Chinese Academy of Sciences, Changchun, 130022, Jilin, P. R. China. xiez@ciac.ac.cn.
Xianying MengDepartment of Thyroid Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun, 130021, Jilin, P.R. China. mengxiany@jlu.edu.cn.

Funding

National Natural Science Foundation of China 32371429Natural Science Foundation of Jilin Province YDZJ202201ZYTS114the Scientific Research Foundation of The First Hospital of Jilin University JDYY13202208
6 · The paper itself

Abstract

The combination of chemotherapy and immune checkpoint blockade therapy shows great potential in tumor treatment, but their integration remains a great challenge. Herein, hypoxia-responsive prodrugs integrating paclitaxel (PTX) and bromodomain-containing protein 4 inhibitor JQ1 were designed and fabricated into nanoparticles (DJNP NPs) in the presence of DSPE-PEG

Indexed as

B7-H1 AntigenImmunotherapyNeoplasmsPaclitaxelProdrugsAnimalsApoptosisAzepinesCell Line, TumorHumansMiceNanoparticlesTriazolesAzepinesB7-H1 AntigenCD274 protein, human(+)-JQ1 compoundPaclitaxelProdrugsTriazolesChemo-immunotherapyHypoxiaPaclitaxelPD-L1Prodrug

Identifiers

PMID41327332
PMCPMC12777260

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.