SynthesisAntimicrobial resistance and infection control2025
Risk factors for healthcare-associated infection and colonization of Serratia marcescens in neonates: a systematic review and meta-analysis.
Synthesis in Antimicrobial resistance and infection control, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
2 citing papers in PubMed.
- From Environmental Organism to Nosocomial Threat:Antibiotics (Basel, Switzerland) · 2026Review
- Multidrug-Resistant Tuberculosis in Rural Eastern Cape, South Africa: Clinical, Bacteriological, and Programmatic Predictors of Poor Treatment Outcomes.Microorganisms · 2026Article
Corrections and comments
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Authors and funding
8 authors.
Funding
Abstract
backgroundSerratia marcescens (S. marcescens) is a gram-negative opportunistic pathogen causing healthcare-associated infections in neonatal intensive care units (NICUs), with mortality rates of 22.4%-58.0% and multi-drug complicating treatment. Fragmented evidence on risk factors limits infection prevention and control (IPC) strategies.
methodsFollowing PRISMA guidelines, we searched PubMed, Web of Science, Wanfang, and CNKI databases from inception to April 25, 2025 for studies in English or Chinese, examining risk factors for S. marcescens infection or colonization in neonates. All reported risk factors were extracted, with those reported in ≥ 3 studies defined as primary outcomes, and those reported in two studies defined as secondary outcomes. Pooled odds ratios (ORs) with 95% confidence intervals (CIs) were calculated using random- or fixed-effects models based on I
resultsTwelve studies were included. Prematurity (OR = 2.90, 95%CI: 2.12-3.96) and very low birth weight (VLBW) (OR = 2.34, 95%CI: 1.48-3.72) were key host-related risk factors. Invasive procedures, including oral/nasogastric tube (aOR = 5.10, 95% CI: 3.06-8.52), arterial catheterization, surgery, continuous positive airway pressure(CPAP), mechanical ventilation, and central venous catheterization (CVC), significantly increased risk. Antibiotic exposure (aOR = 2.04, 95% CI: 1.06-3.93) was a modifiable risk factor, while breastfeeding (OR = 0.45, 95% CI: 0.27-0.75) and vaginal delivery (aOR = 0.51, 95% CI: 0.34-0.76) were protective.
conclusionThis systematic review synthesized evidence on risk factors for S. marcescens in neonates, with outcomes categorized by reporting frequency. Findings advocate for targeted IPC strategies such as antimicrobial stewardship and promotion of protective practices. Limited by case-control designs, future genomic multi-center studies are needed to confirm causality and transmission.
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