Evidence map›Paper›PMID 41327212›Full record

ArticleJournal of nanobiotechnology2025

MXene-integrated microneedles reprogram diabetic-associated macrophages for deep-wound infection therapy and immunoprotection.

Wenshuai Li, Lulu Wang, Hui Zhao, Rui Zhang, Yinyin Zhang, Sen Lin, Haoyang Qin, Xianlong Zong, Kang Gan, Junjie Wang and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of nanobiotechnology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. NIR-Assisted Multimodal Strategies for Enhanced Antibacterial Therapy.Small (Weinheim an der Bergstrasse, Germany) · 2026
    Review
  2. Review
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Wenshuai Li *Department of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Lulu Wang *Department of Plastic Surgery, The Third People's Hospital of Henan Province, Zhengzhou, 450007, Henan, China.
Hui Zhao *Zhengzhou Revogene Technology Co., LTD, Airport District, Zhengzhou, 451162, Henan, China.
Rui ZhangDepartment of Oral and Maxillofacial, Zhengzhou Stomatology Hospital, Zhengzhou, 450000, China.
Yinyin ZhangDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Sen LinDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Haoyang QinDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Xianlong ZongDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Kang GanDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China.
Junjie WangDepartment of Plastic Surgery, The Third People's Hospital of Henan Province, Zhengzhou, 450007, Henan, China.
Heng YinJiangsu CM Clinical Innovation Center of Degenerative Bone & Joint Disease, Wuxi Affiliated Hospital of Nanjing University of Chinese Medicine, Wuxi, China. wxzy011@njucm.edu.cn.
Yazhou ChenHenan Institute of Advanced Technology, Zhengzhou University, Zhengzhou, 45000, China. yzchenbio@zzu.edu.cn.
Rui LiDepartment of Stomatology, The First Affiliated Hospital of Zhengzhou University, No 1, Jian she Road, Zhengzhou, 450000, Henan, China. fcclir@zzu.edu.cn.

Funding

Henan Charity Federation Daojian Fund General Project szsyky24017Key project of Medical Science and Technology Research Program of Henan Province SBGJ202502060Major Project of Henan Province 231111313000National Natural Science Foundation of China 81973878Scientific Research and Innovation Team of the First Affiliated Hospital of Zhengzhou University QNCXTD2023021Young and middle-aged academic leader in Henan Province HNSWJW-2021014Young and Middle-aged Health Science and Technology Innovation Leading Talents in Henan Province YXKC2021014
6 · The paper itself

Abstract

Traditional hyperthermia-boosted photothermal therapy (PTT) for infected wounds often suffers from thermal damage to healthy tissue, exacerbates immune dysregulation, and compromises antibacterial efficacy in deep tissue. Here, we developed a functional microneedle system (MTF@MNs) by incorporating MXene-tannic acid/iron (MXene-TA/Fe, MTF) nanosheets into a photocrosslinkable GelMA/PEGDA hydrogel matrix. The engineered microneedle architecture facilitates targeted delivery of therapeutic nanosheets into deep, biofilm-rich subcutaneous regions, which are characterized by elevated H

Indexed as

Diabetes Mellitus, ExperimentalMacrophagesWound InfectionAnimalsAnti-Bacterial AgentsHydrogelsMaleMiceNeedlesNitritesPhotothermal TherapyRAW 264.7 CellsReactive Oxygen SpeciesTransition ElementsWound HealingAnti-Bacterial AgentsHydrogelsMXeneNitritesReactive Oxygen SpeciesTransition ElementsDeep-wound infectionImmunoprotectionMicroneedleMild thermal therapyMXeneWound healing

Identifiers

PMID41327212
PMCPMC12771996

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.