ArticleBMC biology2025
Staphylococcus aureus-induced degeneration of nociceptive neurons in Caenorhabditis elegans.
Elizabeth M DiLoreto, Xavier Gonzalez, Khursheed A Wani, Jiali Shen, Javier E Irazoqui, Jagan Srinivasan
Abstract read
In one paragraphArticle in BMC biology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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2 · The registryThe trial behind it
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4 · The recordCorrections and comments
5 · Who and what moneyAuthors and funding
6 authors.
Elizabeth M DiLoretoDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA.
Xavier GonzalezDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA.
Khursheed A WaniDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA.
Jiali ShenDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA.
Javier E IrazoquiDepartment of Microbiology, UMass Chan Medical School, Worcester, MA, USA. Javier.Irazoqui@umassmed.edu.ORCID 0000-0001-6553-1329 Jagan SrinivasanDepartment of Biology and Biotechnology, Worcester Polytechnic Institute, Worcester, MA, USA. jsrinivasan@wpi.edu.ORCID 0000-0001-5449-7938 Funding
Enhancing and expanding the CGC Strain CollectionP40OD010440 · OD · UNIVERSITY OF MINNESOTA · PI Aric L Daul, Ann E. Rougvie · 2012 to 2026
$7.5MRole of MiT Transcription Factors in Host Defense Against Bacterial InfectionR01GM101056 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2012 to 2022
$3.9MInnate Immunity Training ProgramT32AI095213 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SILVERMAN, NEAL · 2011 to 2025
$2.5MMechanisms of the gut-brain axis that regulate innate immunityR35GM149284 · NIGMS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI Javier Elbio Irazoqui · 2023 to 2026
$1.7MFunctional connectome of sex-specific processing of social cuesR01DC016058 · NIDCD · WORCESTER POLYTECHNIC INSTITUTE · PI SRINIVASAN, JAGAN · 2017 to 2021
$1.6MFLAVIN-CONTAINING MONO-OXYGENASES AS NOVEL INNATE IMMUNITY EFFECTORSR21AI169842 · NIAID · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI IRAZOQUI, JAVIER ELBIO · 2023 to 2024
$461kNIAID NIH HHS R21 AI169842NIAID NIH HHS T32 AI095213NIDCD NIH HHS R01 DC016058NIGMS NIH HHS R01 GM101056NIGMS NIH HHS R35 GM149284NIH HHS P40 OD010440NIH HHS R01DC016058NIH HHS R01GM101056NIH HHS T32AI095213
6 · The paper itselfAbstract
backgroundThe nervous system senses microbial signals to influence host defense. Pain-sensing nociceptor neurons are key regulators of the host response to infection, but how they perceive infections is not well understood. Using Caenorhabditis elegans as a tractable model host that shares many features with mammalian systems, we investigated the effects of infection on nociceptor function in vivo.
resultsIn vivo intracellular Ca
conclusionsS. aureus damages nociceptor integrity in C. elegans: ASH neurons experience acute Ca
Indexed as
Caenorhabditis elegansNociceptorsStaphylococcal InfectionsStaphylococcus aureusAnimalsCaenorhabditis elegans ProteinsCalciumCaenorhabditis elegans ProteinsCalciumASH neuronC. elegansInfectionNociceptorsS. aureus
Identifiers
PMID41327171
PMCPMC12777361
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