SynthesisBMC infectious diseases2025
The magnitude of anemia among visceral leishmaniasis patients in Ethiopia: a systematic review and meta-analysis.
Synthesis in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundAnemia is the most common hematological manifestation among visceral leishmaniasis patients. The cause of anemia is multifactorial: sequestration and destruction of red blood cells in an enlarged spleen, immune mechanisms, and alterations in RBC membrane permeability have been implicated. Studies on the magnitude of anemia among visceral leishmaniasis patients were inconsistent. Therefore, this review aimed to estimate the pooled prevalence of anemia among visceral leishmaniasis patients in Ethiopia.
methodsThis systematic review and meta-analysis followed the PRISMA guidelines. Comprehensive searches were conducted in PubMed/MEDLINE, Embase, Science Direct, African journals online, and grey literatures like Google Scholar and Google, of studies published from inception to January 2025, supplemented by manual searches to identify relevant studies. Three authors independently selected studies, extracted data, and assessed the critical appraisal of studies. The JBI critical appraisal tool was used for quality appraisal. Statistical analyses were performed using Stata 11.0 software. The I
resultsA total of 9 eligible studies with 2,075 study participants were included to estimate the pooled prevalence of anemia among visceral leishmaniasis patients. The combined prevalence of anemia among visceral leishmaniasis patients was 88.91% (95% CI: 84.45-93.37). Regionally, the highest prevalence of anemia among studies conducted in the Tigray region was 96.0% (95% CI; 92.0-99.9). Moreover, the prevalence of anemia among visceral leishmaniasis patients according to the study design was 88.0% (95% CI; 81.8-94.1), 93.6% (95% CI; 87.9-99.3), and 85.5% (95% CI; 82.0-88.9) in a retrospective cross-sectional study, cross-sectional study, and the retrospective cohort study respectively.
conclusionsThis systematic review and meta-analysis found a high prevalence of anemia among visceral leishmaniasis patients in Ethiopia. Red blood cell parameters should be assessed regularly to prevent and monitor anemia disorders in those study groups.
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