ArticleBMC nephrology2025
Retrospective analysis of the diagnostic spectrum of histological nephropathies from the Magdeburg kidney biopsy cohort (MD-KBC).
Article in BMC nephrology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.
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Who cites it
3 citing papers in PubMed.
- Granular Swollen Epithelial Cells in Native Kidney Biopsies: Prevalence, Clinicopathological Associations and Kidney Outcomes.Diagnostics (Basel, Switzerland) · 2026Article
- Urinary Exosomal miRNAs as Non-Invasive Biomarkers Linked to Podocyte Morphometry in CKD.Cells · 2026Article
- IgA Nephropathy: Epidemiology, Outcomes, and Insights for Primary Glomerulonephritides.Journal of clinical medicine · 2026Review
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7 authors.
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Abstract
backgroundThe epidemiology of biopsy-proven kidney disease varies geographically, yet data from Central Germany are lacking, hindering local disease understanding and healthcare planning. We aimed to characterize the spectrum, trends, and predictors of kidney diseases in this region.
methodsWe retrospectively analyzed 1,029 native kidney biopsies from a tertiary center in Saxony-Anhalt (2010-2021), assessing demographic, clinical, and histopathological data. Temporal trends were compared between two 6-year periods. Multivariate logistic regression identified predictors for major diagnoses.
resultsMean patient age was 54.3 years (65% male). Primary glomerulonephritis (GN) was the most common diagnosis (50.4%), led by IgA nephropathy (IgAN) (23.0%), diabetic nephropathy (DN) (10.0%), and vasculitis-associated GN (8.7%). Trend analysis revealed a significant decrease in primary GN (56.4% to 46.5%; p < 0.001) and an increase in vascular nephropathies (2.7% to 10.6%; p < 0.001). Male sex was an independent predictor for IgAN (OR 1.41), while younger age and female sex predicted Minimal Change Disease or Lupus Nephritis.
conclusionThis first study from Central Germany reveals a unique epidemiological profile with a high burden of IgAN, DN, and vasculitis. We observed a significant temporal shift from primary GNs towards vascular diseases, reflecting the rising prevalence of metabolic syndrome and hypertensive conditions. These findings underscore evolving challenges in nephrology and support the need for a national German kidney biopsy registry to monitor and address these trends.
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