Evidence map›Paper›PMID 41327123›Full record

Trial reportBMC psychiatry2025

Longitudinal changes in sleep quality in male patients with alcohol dependence receiving far-infrared ray therapy: associations with alterations in circulating pro-inflammatory cytokines.

Qingrong Xia, Shaonan Wang, Jian Sun, Yang Xu, Yayun Xu, Yining Sun, Xianjun Yang

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Qingrong XiaInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Shaonan WangInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Jian SunInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Yang XuInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Yayun XuHefei Fourth People's Hospital, Hefei, China.
Yining SunInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China.
Xianjun YangInstitute of Intelligent Machines, Hefei Institutes of Physical Science, Chinese Academy of Sciences, Hefei, China. xjyang@iim.ac.cn.

Funding

Anhui Province Medical and Health Key Specialty Construction Project AHWJ2022b094Hefei Key Generic Technology Research GJ2022SM04
6 · The paper itself

Abstract

objectiveSleep disturbance is common in alcohol dependence (AD). Far-infrared ray (FIR) therapy has anti-inflammatory properties and may improve sleep, offering a potential non-pharmacological treatment during withdrawal. The primary objective of this study was to compare sleep quality and serum pro-inflammatory cytokine levels between AD patients who received FIR therapy and those who received standard care only.

methodsA total of 114 male AD patients who completed a two-week withdrawal program were randomized to a control group (n = 61) receiving supportive care, or a treatment group (n = 53) receiving supportive care plus five FIR sessions. Sleep quality was assessed using cardiopulmonary coupling (CPC), and serum levels of 10 cytokines were measured via Luminex assay before and after the intervention. Analysis of covariance (ANCOVA) compared post-treatment outcomes between groups, controlling for baseline values. Pearson correlation analysis examined relationships between changes in sleep parameters and cytokine levels.

resultsCompared to controls, the treatment group showed significantly increased total sleep time and sleep efficiency. Moreover, serum levels of IL-1β, IL-6, and TNF-α were significantly reduced in the treatment group. Addtionally, improvements in total sleep time and sleep efficiency were negatively correlated with changes in IL-1β and TNF-α levels.

conclusionsFIR therapy may improve sleep quality and reduce pro-inflammatory cytokines in AD patients during withdrawal, suggesting its potential as an alternative to hypnotic medications for sleep management.

Indexed as

AlcoholismCytokinesInfrared RaysSleep QualitySleep Wake DisordersAdultHumansInterleukin-6Longitudinal StudiesMaleMiddle AgedTreatment OutcomeTumor Necrosis Factor-alphaCytokinesInterleukin-6Tumor Necrosis Factor-alphaAlcohol dependenceCardiopulmonary couplingFar-infrared rayPro-inflammatory cytokinesSleep quality

Identifiers

PMID41327123
PMCPMC12771806

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.