Evidence map›Paper›PMID 41327042›Full record

ArticleBMC pregnancy and childbirth2025

Factors associated with stillbirth in São Paulo, Brazil: FetRiskS - a multidisciplinary case-control study.

Lays Janaina Prazeres Marques, Gizelton Pereira Alencar, Dario Ezequiel Elias, Zilda Pereira da Silva, Gabriella Ferreira Demarque, Gerusa Maria Figueiredo, Mara Sandra Hoshida, Osmara Alves Dos Santos, Luciana Duzolina Manfré Pastro, Rafael Junqueira Buralli and 10 more

Abstract read
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In one paragraph

Article in BMC pregnancy and childbirth, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Lays Janaina Prazeres Marques *Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
Gizelton Pereira Alencar *Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
Dario Ezequiel EliasDepartamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
Zilda Pereira da SilvaDepartamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
Gabriella Ferreira DemarqueDepartamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil.
Gerusa Maria FigueiredoDepartamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Mara Sandra HoshidaLaboratório de Investigação Médica em Obstetrícia (LIM-57), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Osmara Alves Dos SantosDepartamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Luciana Duzolina Manfré PastroDepartamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Rafael Junqueira BuralliDepartamento de Política, Gestão e Saúde, Faculdade de Saúde Pública, Universidade de São Paulo, São Paulo, Brazil.
Clarisse M MachadoInstituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Luciana Regina MeirelesInstituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Rodrigo Melim ZerbinatiLaboratório de Virologia (LIM-52), Instituto de Medicina Tropical da Faculdade de Medicina da Universidade de São Paulo, Universidade de São Paulo, São Paulo, Brazil.
Andrés Jimenez Galisteo JuniorLaboratório de Investigação Médica em Protozoologia, Bacteriologia e Resistência Antimicrobiana (LIM-49), Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Regina SchultzDivisão de Anatomia Patológica, Hospital das Clínicas HCFMUSP, Universidade de São Paulo, São Paulo, Brazil.
Laura Cunha RodriguesLondon School of Hygiene & Tropical Medicine, London, UK.
Rossana Pulcineli Vieira FranciscoDepartamento de Obstetrícia e Ginecologia, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Hillegonda Maria Dutilh NovaesDepartamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Nelson Gouveia *Departamento de Medicina Preventiva, Faculdade de Medicina, Universidade de São Paulo, São Paulo, Brazil.
Marcia Furquim de Almeida *Departamento de Epidemiologia, Faculdade de Saúde Pública, Universidade de São Paulo, Av. Dr. Arnaldo, 715 - Cerqueira César, São Paulo, 01246-904, Brazil. marfural@usp.br.

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior 001Fundação de Amparo à Pesquisa do Estado de São Paulo 2016/07765-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2018/19592-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2020/05458-9Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/13271-1Fundação de Amparo à Pesquisa do Estado de São Paulo 2022/16153-0Fundação de Amparo à Pesquisa do Estado de São Paulo 2023/17594-2
6 · The paper itself

Abstract

backgroundStillbirth remains a significant public health issue, with socioeconomic, demographic, environmental, behavioral, healthcare, and biological factors influencing its occurrence. This study aimed to investigate the risk factors for stillbirths in São Paulo, Brazil.

methodsThis population-based case-control study included stillbirths (cases) and live births (controls) from 14 public hospitals in the city of São Paulo, Brazil. Data were obtained from interviews with women after delivery, hospital records, antenatal care registries, placental samples, and maternal blood samples for analysis of infection biomarkers. A logistic regression model was used to estimate the odds ratio (OR) with a 95% confidence interval.

resultsThe study included 401 stillbirths (348 antepartum and 53 intrapartum) and 419 live births. The final model identified significant risk factors for stillbirth, including the absence of a partner (OR = 1.76; 95%CI: 1.15–2.68), smoking during pregnancy (OR = 1.94; 95%CI: 1.10–3.47), inadequate antenatal care access (OR = 2.15; 95%CI: 1.38–3.39), hyperglycemia (OR = 1.91; 95%CI: 1.21–3.03), the presence of placental lesions (OR = 3.15; 95%CI: 2.20–4.52), fetal growth restriction (OR = 6.16; 95%CI: 3.76–10.4), and congenital malformations (OR = 4.25; 95%CI: 2.42–7.67).

conclusionsThis study identifies critical maternal and fetal factors associated with stillbirth risk in a middle-income country, showing its complex profile.

Indexed as

StillbirthAdultBrazilCase-Control StudiesFemaleHumansHyperglycemiaLogistic ModelsOdds RatioPregnancyPregnancy ComplicationsPrenatal CareRisk FactorsSmokingYoung AdultCase-controlFetal mortalityPregnancyRisk factorsStillbirths

Identifiers

PMID41327042
PMCPMC12853630

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.