ArticleBMC infectious diseases2025
Hepatitis B in Ethiopia: viral load, affordability, and patient perspectives at a tertiary hospital in Addis Ababa, Ethiopia.
Article in BMC infectious diseases, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
- Liver disease diagnostics and access barriers in African settings: a narrative review.Journal of clinical pathology · 2026Review
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5 authors.
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Abstract
backgroundHepatitis B virus (HBV) is a leading cause of liver infections, which can lead to chronic illness and, in some cases, liver cancer. It affects millions of people worldwide, with a particularly high burden in Africa, especially Ethiopia. Despite its prevalence, access to HBV viral load testing is limited, and its affordability has not been well documented, particularly in Ethiopia, making it challenging to diagnose and treat the disease effectively. Therefore, this study aimed to quantify the HBV viral load, assess affordability, knowledge, attitudes, and practices related to the disease, and identify various determinants associated with these parameters." study aimed to quantify the HBV viral load, affordability, knowledge, attitudes, and practices related to this disease among HBV-infected patients at St. Paul Hospital Millennium Medical College, Addis Ababa, Ethiopia, in 2024.
methodsA cross-sectional study was conducted from January to April 2024 using quantitative and qualitative data from 256 participants. Affordability was assessed using household income and expenditure on HBV viral load (VL) tests, with VL quantification performed using the Cobas
resultsA total of 256 participants were included in this study, 53.1% of whom were females. Compared with female participants, male participants demonstrated a significantly greater likelihood of having a high viral load (AOR = 2.49, 95% CI: 1.26-4.92, p = 0.01). Individuals with co-infections exhibited a substantially increased likelihood of having a high viral load (AOR = 8.38, 95% CI: 3.76-12.29, p < 0.01). Regarding KAP concerning HBV infection, 50% of the participants demonstrated good knowledge, and 38.3% exhibited a positive attitude, and 57.8% reported good practices. Urban residents (AOR = 0.11, 95% CI: 0.02-0.60, p = 0.01), higher-income earners (AOR = 0.14, 95% CI: 0.05-0.43, p < 0.01), and individuals who had undergone viral load testing within the previous month (AOR = 0.01, 95% CI: 0.09-0.17, p < 0.03) all demonstrated significantly lower odds of experiencing catastrophic expenditures.
conclusionThis study highlights the importance of tailored HBV management strategies, including targeted interventions and comprehensive infection prevention and control. Enhancing public health education and reducing financial barriers to HBV diagnosis and care, especially for vulnerable populations, remain crucial. CLINICAL TRIAL NUMBER: Not applicable.
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