ArticleBMC genomics2025
Independent divergences of the aquaporins across different genera highlight the distinct adaptation mechanisms within Mytilida.
Article in BMC genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
- Erratum issued
Authors and funding
8 authors.
Funding
Abstract
backgroundMussels are naturally distributed throughout ocean and freshwater ecosystems, with each species exhibiting distinct adaptive characteristics to dynamic environments. Aquaporins (AQPs) are essential selective transmembrane transport proteins that facilitate the permeation of water and other small solutes. These proteins play a significant role in maintaining metabolic homeostasis and supporting environmental adaptation via independent duplication and subsequent diversification. This study employs a comprehensive phylogenomic approach to uncover the original evolution and subsequent divergence of AQPs within the order Mytilida, a group that encompasses numerous mussel species.
resultsUtilizing genome-wide data from multiple organisms across different genera, our analysis revealed ancient foundational duplications that occurred in the last common ancestor of mussels and abundant subsequent lineage-specific expansions and diversifications following the divergence of different genera. Intriguingly, independent duplications of c-AQP orthologs primarily occurred in genera other than Mytilus. As a form of compensation, diversifications of the AQGP and AQP8 orthologs mainly occurred within the genus Mytilus. By integrating structural modeling, we provide insights into how the diversified amino acid compositions in the selective filters influence the inner-surface properties of the channel among duplicated paralogs. Moreover, comparative genomic analyses highlighted the role of presence/absence variations (PAVs) in promoting the further diversification of the AQP8 subfamily, presenting as adaptive genetic signatures among geographical distinct populations.
conclusionsThese findings underscore the importance of ancestral gene duplication, subsequent functional diversification, and large-scale genomic variation in shaping the evolutionary success and ecological adaptability of mussel AQPs, particularly within the Mytilus genus.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.