Evidence map›Paper›PMID 41326938›Full record

ArticleTranslational stroke research2025

Clusters of Pediatric Brain Arteriovenous Malformations Link Spatial Distribution, Clinical Presentation, and Outcomes.

Sandro Benichi, Joseph Benzakoun, Grégoire Boulouis, Matei Militaru, Lelio Guida, Marie Bourgeois, Kévin Beccaria, Nathalie Boddaert, Catherine Oppenheim, Guillaume Canaud and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Sandro Benichi *Department of Pediatric Neurosurgery, Necker University Hospital, Paris, France. sandro.benichi@aphp.fr.
Joseph Benzakoun *Institute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, IMA-Brain, Université Paris Cité, Paris, 75014, France.
Grégoire BoulouisDepartment of Neuroradiology, CHRU Tours, Tours, France.
Matei MilitaruDepartment of Pediatric Neurosurgery, Necker University Hospital, Paris, France.
Lelio GuidaDepartment of Pediatric Neurosurgery, Necker University Hospital, Paris, France.
Marie BourgeoisDepartment of Pediatric Neurosurgery, Necker University Hospital, Paris, France.
Kévin BeccariaDepartment of Pediatric Neurosurgery, Necker University Hospital, Paris, France.
Nathalie BoddaertDepartment of Pediatric Radiology, APHP Necker University Hospital, Paris, France.
Catherine OppenheimInstitute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, IMA-Brain, Université Paris Cité, Paris, 75014, France.
Guillaume CanaudUMR 1151, Necker-enfant malades Institute, Paris, France.
Manoelle KossorotoffDepartment of Pediatric Neurology, APHP Necker University Hospital, Paris, France.
Thomas BlauwblommeDepartment of Pediatric Neurosurgery, Necker University Hospital, Paris, France.
Olivier NaggaraInstitute of Psychiatry and Neuroscience of Paris (IPNP), INSERM U1266, IMA-Brain, Université Paris Cité, Paris, 75014, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Pediatric brain arteriovenous malformation (PbAVM) is a potentially life-threatening condition accounting for intracerebral hemorrhage and other neurological complications. Our study aimed to elucidate the relationships between PbAVM angioarchitecture, spatial distribution, and clinical presentation. This retrospective study included all consecutive PbAVMs managed in a tertiary pediatric center (2007-2023). We performed a hierarchical clustering based on quantitative imaging data and constructed a 3D MRI-based atlas. We derived and analyzed clusters for initial presentation, clinical parameters (cure, recurrent bleeding, proliferation/recurrence, seizures) and location. We included 245 pediatric brain arteriovenous malformations in 234 patients (74.8% ruptured, mean age 9.9±4 years). Hierarchical clustering delineated three clusters of PbAVMs. Cluster 1 included ruptured small slow flow PbAVMs (n = 162, 82% ruptured). Cluster 2 included ruptured and epileptic fast flow PbAVMs (n = 69, 53% ruptured, 23% epileptic), more frequently located within the right thalamus. Cluster 3 included giant PbAVMs (n = 14, 21.5% ruptured, 57% epileptic), more frequently located within the left posterior insula and right premotor area. Cluster 2 PbAVMs achieved lower rate of exclusion than Cluster 1 (HR

Indexed as

Intracranial Arteriovenous MalformationsAdolescentBrainChildChild, PreschoolCluster AnalysisFemaleHumansMagnetic Resonance ImagingMaleRetrospective StudiesBrain mosaicismBrain probability atlasPediatric intracranial hemorrhageStrokeVascular malformation

Identifiers

PMID41326938
PMCPMC12669305

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.