Evidence map›Paper›PMID 41326923›Full record

ArticleStem cell reviews and reports2026

FGF2 Enhances MSCs Secretome Therapy for Skin Photoaging by Delaying Senescence via iNAMPT/AMPK Signaling and Facilitating eNAMPT-Mediated Regenerative Crosstalk.

Yixin Zhang, Manping Lu, Jieqing Ouyang, Lin Liang, Fan Li, Zhihan Pei, Lihao Chen, Miaoman Ye, Jiajie Tan, Liwei Xiang and 7 more

Abstract read
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In one paragraph

Article in Stem cell reviews and reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Yixin Zhang *Research Center for Clinical and Translational Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, and the 6Th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Manping Lu *Translational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Jieqing OuyangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Lin LiangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Fan LiTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Zhihan PeiResearch Center for Clinical and Translational Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, and the 6Th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Lihao ChenTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Miaoman YeTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Jiajie TanTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Liwei XiangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Lijing KongResearch Center for Clinical and Translational Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, and the 6Th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China.
Long HuangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China.
Li FuGuangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, School of Biomedical Engineering, Shenzhen University Medical School, Shenzhen, 518060, China.
Wenhao WangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. ezwangwenhao@live.cn.
Lei QinDepartment of Orthopedics, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, and the 6Th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China. dr_qinlei@email.szu.edu.cn.
Zhiyong ZhangTranslational Research Centre of Regenerative Medicine and 3D Printing of Guangzhou Medical University, Guangdong Province Engineering Research Center for Biomedical Engineering, State Key Laboratory of Respiratory Disease, The Third Affiliated Hospital of Guangzhou Medical University, Guangzhou, 510150, China. mr.zhiyong@gmail.com.
Jihui DuResearch Center for Clinical and Translational Medicine, Huazhong University of Science and Technology Union Shenzhen Hospital, Shenzhen Nanshan People's Hospital, and the 6Th Affiliated Hospital of Shenzhen University Medical School, Shenzhen, 518052, China. jihuidu@email.szu.edu.cn.

Funding

GuangDong Basic and Applied Basic Research Foundation 2022A1515220185Nanshan District Health Science and Technology Major Project - Outstanding Youth Fund Project NSZD2024030Nanshan District Health System Major Scientific and Technological Projects Grants NSZD2023009Project of Huazhong University of Science and Technology Union Shenzhen Hospital YN2021043Project of The Laboratory of Guangdong-Hong Kong-Macao Joint Laboratory of Respiratory Infectious Disease GHMJLRID-Z-202122Project of The State Key Laboratory of Respiratory Disease SKLRD-Z-202105Science and Technology Innovation Project of Foshan City 1920001000025the National Natural Science Foundation of China 82072415the Research Funds of the Science, Technology and Innovation Commission of Shenzhen JCYJ20190809105001757
6 · The paper itself

Abstract

Mesenchymal stem cells (MSCs) show great potential for combating aging-related tissue degeneration, yet their clinical translation is hampered by serum-dependent culture. Here, we report a GMP-compliant serum-free (SF) system for human umbilical cord MSCs (hUC-MSCs) and demonstrate that their secretome exerts superior efficacy against UVB-induced skin photoaging compared to serum-containing counterparts, such as increased dermal thickness, improved angiogenesis and upregulated levels of senescence-associated proteins. Further, this enhanced activity was investigated to correlate with elevated NAMPT. Crucially, FGF2, a predefined SF medium component, was identified as a NAMPT-mediated dual-functional modulator for both delaying MSCs senescence and enhancing the anti-photoaging effect of secretome. Mechanistically, we found that extracellular NAMPT directly counteract photoaging via extracellular vesicle delivery approach, while intracellular NAMPT regulated senescence-, proliferation-, and apoptosis-related genes through FGFR/NAMPT/AMPK signaling pathway, synergistically influencing on the anti-photoaging function of secretome. Our work proposes a cell-free secretome-based strategy for skin anti-photoaging and demonstrates the dual roles of FGF2 in enhancing cell viability and paracrine activity.

Indexed as

AMP-Activated Protein KinasesCellular SenescenceFibroblast Growth Factor 2Mesenchymal Stem CellsNicotinamide PhosphoribosyltransferaseRegenerationSecretomeSkin AgingCell ProliferationCytokinesHumansSignal TransductionUltraviolet RaysUmbilical CordAMP-Activated Protein KinasesCytokinesFibroblast Growth Factor 2Nicotinamide PhosphoribosyltransferaseFGF2Mesenchymal stem cellsNAMPTPhotoagingSecretome

Identifiers

PMID41326923

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.