Evidence map›Paper›PMID 41326898›Full record

ArticlePituitary2025

Defining normative cortisol responses to the insulin tolerance test: A comparison of Elecsys

Sema Okutan, Stina Willemoes Borresen, Linda Hilsted, Ulla Feldt-Rasmussen, Marianne Klose

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pituitary, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sema OkutanDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0009-0004-8808-2123
Stina Willemoes BorresenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-3939-3388
Linda HilstedDepartment of Clinical Biochemistry, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0003-3465-999X
Ulla Feldt-RasmussenDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.ORCID http://orcid.org/0000-0002-5903-3355
Marianne KloseDepartment of Nephrology and Endocrinology, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark. marianne.christina.klose.01@regionh.dk.ORCID http://orcid.org/0000-0001-6075-0821

Funding

Novo Nordisk Fonden NNF20OC0063280
6 · The paper itself

Abstract

BACKGROUND AND

aimMonoclonal immunoassays offer greater specificity than polyclonal assays for cortisol measurement, necessitating assay-specific cut-off limits, which have not yet been defined for the insulin tolerance test (ITT). The study aim was to define the normative cortisol response to the ITT with the first- and second-generation Roche Elecsys

methodsNinety participants underwent an ITT after an overnight fast. Blood samples were analysed by both Elecsys

resultsThe mean peak cortisol was 608 ± 102 nmol/L with Elecsys

conclusionElecsys

Indexed as

HydrocortisoneInsulinAdrenocorticotropic HormoneAdultFemaleHumansImmunoassayMaleMiddle AgedYoung AdultAdrenocorticotropic HormoneHydrocortisoneInsulinAdrenal insufficiencyCortisolCut-offHPA-axisImmunoassayInsulin tolerance test

Identifiers

PMID41326898

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.