Evidence map›Paper›PMID 41326886›Full record

Trial reportActa neurochirurgica2025

Mortality and causes of death after surgery for chronic subdural hematoma: a post hoc study of the FINISH randomized trial.

Pihla Tommiska, Oula Knuutinen, Kimmo Lönnrot, Teemu Luoto, Ville Leinonen, Timo Koivisto, Sami Tetri, Jussi P Posti, Rahul Raj, FINISH study group

Registry-linked trialAbstract readMulticenter StudyRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Acta neurochirurgica, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04203550 (The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma), which is not on this map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04203550 nacompletednot on this map

The Finnish Study of Intraoperative Irrigation Versus Drain Alone After Evacuation of Chronic Subdural Hematoma (FINISH): a Study Protocol for a Multicenter Randomized Controlled Trial

TypeinterventionalSponsorHelsinki University Central HospitalRan2020 to 2023Enrolled587ConditionsChronic Subdural HematomaArmsIntraoperative irrigation, No irrigation
3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Pihla Tommiska *Department of Neurosurgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Po Box 320, 00029 HUS, Helsinki, Finland. pihla.tommiska@helsinki.fi.
Oula Knuutinen *Department of Neurosurgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
Kimmo LönnrotDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Po Box 320, 00029 HUS, Helsinki, Finland.
Teemu LuotoDepartment of Neurosurgery, Tampere University Hospital and Tampere University, Tampere, Finland.
Ville LeinonenDepartment of Neurosurgery, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Timo KoivistoDepartment of Neurosurgery, Kuopio University Hospital and Institute of Clinical Medicine, University of Eastern Finland, Kuopio, Finland.
Sami TetriDepartment of Neurosurgery, Oulu University Hospital and University of Oulu, Oulu, Finland.
Jussi P PostiDepartment of Neurosurgery and Turku Brain Injury Center, Neurocenter, Turku University Hospital, Turku, Finland.
Rahul RajDepartment of Neurosurgery, Helsinki University Hospital and University of Helsinki, Haartmaninkatu 4, Po Box 320, 00029 HUS, Helsinki, Finland.
FINISH study group

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeChronic subdural hematoma (CSDH) is a common neurosurgical disease, especially prevalent among the elderly and is associated with reduced life expectancy. This study investigated mortality and causes of death after burr-hole drainage surgery for CSDH.

methodsWe included patients from the FINISH trial, a national, multicenter, randomized study conducted in Finland during 2020-2022. We obtained mortality data from Statistics Finland. For the classification of causes of death, we used the European shortlist of 86 causes, which is derived from the 10th revision of the International Classification of Diseases and Related Health Problems (ICD-10).

resultsOverall, the FINISH trial population included 589 patients (median age 78 years, 28% women). After a median follow-up of 16.4 months (IQR 9.7-23.1), 82 patients (14%) died. The median age at death was 85 years (IQR 81-89), and the median time from surgery to death was 6.5 months (IQR 2.4-15.3). The leading causes of death were circulatory diseases (34%), accidents (16%), and dementia (15%). A higher number of pre-existing comorbidities was significantly associated with increased mortality. In particular, dementia, cardiac arrhythmia, prior cerebrovascular events, and hypertension emerged as significant risk factors for death.

conclusionThis study provides valuable insights into mortality rates and causes of death among patients undergoing CSDH surgery. The findings underscore the critical role of pre-existing comorbidities in influencing patient outcomes.

trial registrationThe FINISH trial was registered with ClinicalTrials.gov (NCT04203550) on Dec 16, 2019. The trial is completed.

Indexed as

Hematoma, Subdural, ChronicPostoperative ComplicationsAgedAged, 80 and overCause of DeathComorbidityDrainageFemaleFinlandHumansMaleNeurosurgical ProceduresTrephiningCause of deathChronic subdural hematomaComorbidityMortalityNeurosurgery

Identifiers

PMID41326886
PMCPMC12672672

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Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.