Evidence map›Paper›PMID 41326833›Full record

ArticleFunctional & integrative genomics2025

Exploring the potential of miR-9a-5p in circadian rhythm and cognitive recovery following brain injury in neonatal rats.

Changqin Han, Lin Li, Yajing Yun, Chenxi Feng, Meifang Jin, Xin Ding, Bin Sun, Lixiao Xu

RetractedAbstract readRetracted Publication
PubMed Publisher
In one paragraph

Article in Functional & integrative genomics, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It has been retracted, and should not be counted. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Changqin Han *Institute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China.
Lin Li *Institute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China.
Yajing YunDepartment of Pediatrics, the First People's Hospital of Taicang, Taicang, 215400, China.
Chenxi FengInstitute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China.
Meifang JinInstitute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China.
Xin DingDepartment of Neonatology, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China.
Bin SunDepartment of Neonatology, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China. sunyu0628@126.com.
Lixiao XuInstitute of Pediatric Research, Children's Hospital of Soochow University, No.92 Zhongnan Street, Wuzhong District, Suzhou, 215000, Jiangsu Province, China. xlx3210@suda.edu.cn.

Funding

Major Basic Research Project of the Natural Science Foundation of the Jiangsu Higher Education Institutions BK20200207the National Natural Science Foundation of China 82071486the National Natural Science Foundation of China 82071681 and 82271739the Natural Science Foundation of the Jiangsu Higher Education Institutions of China 22KJB320021the Project of Suzhou Science and Technology Development Plan SKY2021008
6 · The paper itself

Abstract

Neonatal hypoxic-ischemic encephalopathy (HIE) affects approximately 0.2%-0.3% of live births in developed countries, and nearly 40% of survivors experience lasting cognitive impairments, often accompanied by circadian rhythm disturbances. To explore the underlying mechanism, we examined the expression changes of miR-9a-5p in a neonatal rat model of hypoxic-ischemic brain damage (HIBD) and assessed its long-term influence on circadian rhythm and cognitive function. The results show that miR-9a-5p is significantly upregulated in the pineal gland of HIBD rats. Dual-luciferase reporter experiments further confirm that miR-9a-5p directly targets Clock. Compared with sham-operated controls, HIBD rats showed a significant reduction in the transcript levels of Clock and other circadian genes, including Per1, Cry1, and Bmal1. Behavioral analyses demonstrated that overexpression of miR-9a-5p disrupted circadian rhythm, accelerating the onset of physical activity. Furthermore, performance in the Morris water maze, open field, and novel object recognition tests indicated that miR-9a-5p overexpression significantly impaired cognitive function and increased anxiety-like behaviors. These findings suggest that miR-9a-5p exerts notable pathological effects in the HIBD model by targeting Clock, and the circadian rhythm genes it regulates may serve as potential therapeutic targets for circadian rhythm-related cognitive dysfunction following HIBD.

Indexed as

Brain InjuriesCircadian RhythmCognitionHypoxia-Ischemia, BrainMicroRNAsAnimalsAnimals, NewbornARNTL Transcription FactorsCLOCK ProteinsMalePeriod Circadian ProteinsPineal GlandRatsRats, Sprague-DawleyARNTL Transcription FactorsClock protein, ratCLOCK ProteinsMicroRNAsMIRN9 microRNA, ratPeriod Circadian ProteinsBehavioral researchHypoxic-Ischemic brain damageMiR-9a-5pNeonatal ratPineal gland

Identifiers

PMID41326833

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.