Evidence map›Paper›PMID 41326826›Full record

ReviewNature reviews. Chemistry2026

Methods and applications for epoxide C-C bond cleavage reactions.

Noam Orbach, Zachary P Sercel, Rahul Suresh, Ilan Marek

Abstract readReview
PubMed Publisher
In one paragraph

Review in Nature reviews. Chemistry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Noam Orbach *Schulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis, Technion - Israel Institute of Technology, Technion City, Haifa, Israel.ORCID http://orcid.org/0009-0004-3340-7920
Zachary P Sercel *Schulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis, Technion - Israel Institute of Technology, Technion City, Haifa, Israel.ORCID http://orcid.org/0000-0001-7977-8509
Rahul Suresh *Schulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis, Technion - Israel Institute of Technology, Technion City, Haifa, Israel.ORCID http://orcid.org/0000-0003-3423-713X
Ilan MarekSchulich Faculty of Chemistry and the Resnick Sustainability Center for Catalysis, Technion - Israel Institute of Technology, Technion City, Haifa, Israel. chilanm@technion.ac.il.ORCID http://orcid.org/0000-0001-9154-2320

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Epoxides are ubiquitous synthetic building blocks owing to the numerous tactics for their C-O bond cleavage. Remarkably, epoxides also undergo selective C-C bond cleavage by a broad range of transformations, utilizing orthogonal conditions to override the conventional C-O bond scission. These strategies allow the construction of diverse oxygenated cyclic and acyclic molecular backbones, often challenging to access otherwise. Here, we discuss the various modes of epoxide C-C bond cleavage reactions, highlighting synthetic applications of these reactions and suggesting directions for the further development of these powerful, yet underutilized, methods.

Identifiers

PMID41326826

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.