Evidence map›Paper›PMID 41326776›Full record

ArticlePediatric research2026

Comparison of eGFR equations for estimating kidney function in Chinese children.

Junlong Hu, Yan Yang, Wenpin Ye, Wei Guo, Huifang Chen, Fan Yang, Yang Yang, Yan Chen, Yungang Yang, Haitao Bai

Abstract readComparative Study
PubMed Publisher
In one paragraph

Article in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

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2citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Junlong Hu *Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yan Yang *Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Wenpin Ye *Department of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Wei GuoDepartment of Nuclear Medicine and Minnan PET Center, Xiamen Key Laboratory of Radiopharmaceuticals, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Huifang ChenDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, School of Medicine, Xiamen University, Xiamen, China.
Fan YangDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yang YangDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yan ChenDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China.
Yungang YangDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China. xmyyg@sina.com.
Haitao BaiDepartment of Pediatrics, The First Affiliated Hospital of Xiamen University, Xiamen, China. baihaitao@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGlomerular filtration rate (GFR) is a critical indicator of kidney function in kidney diseases. However, well-recognized estimated GFR (eGFR) equations for pediatric populations in specific cohorts remain elusive. This study aimed to evaluate and compare the performance of various eGFR equations against measured GFR (mGFR).

methodsA total of 221 children were included. Fourteen eGFR equations were compared with mGFR using Spearman's correlation analysis, Bland-Altman analysis, and by assessing bias, precision, and accuracy. Subgroup analyses were conducted to further evaluate the performance of eGFR equations.

resultsThe mGFR value showed no statistical difference from the eGFR values obtained using the CKiD (combined-creatinine (Cr)/cystatin C (CysC)/blood urea nitrogen (BUN)) and Tang (combined-Cr/CysC/BUN) equations (P = 0.265 and 0.653, respectively). The CKiD (combined-Cr/CysC/BUN) and Tang (combined-Cr/CysC/BUN) equations demonstrated the highest correlation (r = 0.509 and 0.455, respectively) and agreement (mean difference = -1.4 and 2.2, respectively), with the lowest bias (bias = 0.1 and 2.7, respectively) and the highest precision (median absolute value = 27.3 and 26.2, respectively) and accuracy (P

conclusionThe eGFR equations incorporating Cr, BUN, and CysC simultaneously demonstrated higher accuracy and precision. The CKiD (combined-Cr/CysC/BUN) and Tang (combined-Cr/CysC/BUN) equations exhibited the highest correlation and agreement with mGFR, suggesting their potential as alternatives when mGFR is unavailable in Chinese pediatric populations. IMPACT: Glomerular filtration rate (GFR) serves as a crucial indicator of kidney function. In clinical settings, accurate assessment of GFR is vital for ensuring timely therapeutic interventions and enhancing patient outcomes. The eGFR equations that simultaneously incorporate creatinine (Cr), cystatin C (CysC), and blood urea nitrogen (BUN) exhibit enhanced accuracy and precision. The CKiD (combined-Cr/CysC/BUN) and Tang (combined-Cr/CysC/BUN) equations demonstrated the strongest correlation and agreement with mGFR. This indicates that they may serve as viable alternatives when mGFR is not available in pediatric populations.

Indexed as

Glomerular Filtration RateKidneyKidney Function TestsAdolescentBlood Urea NitrogenChildChild, PreschoolChinaCreatinineCystatin CEast Asian PeopleFemaleHumansMaleReproducibility of ResultsCreatinineCystatin C

Identifiers

PMID41326776

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