ArticleTranslational stroke research2025
Vascular Endothelial Growth Factor-A and Collateral Circulation in Patients with Acute Ischemic Stroke due to Intracranial Large Vessel Occlusion.
Article in Translational stroke research, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Collateral circulation (CC) plays a critical role in stroke progression and vascular endothelial growth factor-A (VEGF-A) is a key angiogenic mediator. The aim of the study was to evaluate the association between VEGF-A plasma levels and CC in patients with acute ischemic stroke (AIS) due to large vessel occlusion (LVO) who received endovascular therapy (EVT). We conducted a prospective multicentre study of patients with LVO-AIS who received EVT. Blood samples were collected on admission to measure VEGF-A plasma levels. CC was assessed by automated collateral scoring on baseline CT angiography and classified from 0 to 3, later dichotomized into poor (0-1) and good (2-3) CC. Multivariable logistic regression analyses were performed to explore the association between VEGF-A and CC. Included were 290 patients (73.4 ± 13.5 years, 50.0% women), previous mRS median score was 0 (IQR 0-1) and the baseline NIHSS median score was 16 (IQR 9-20). Higher baseline VEGF-A levels were independently associated with better CC (cOR
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