Evidence map›Paper›PMID 41326735›Full record

ArticleNature2026

CD8

Zahra Kiani, Jonathan M Urbach, Hannah Wisner, Mpho J Olatotse, Daniel Y Chang, Joshua A Acklin, Alicja Piechocka-Trocha, Nathalie Bonheur, Ashok Khatri, Mathias Lichterfeld and 6 more

Abstract read
In one paragraph

Article in Nature, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
  4. Persistent cytolytic CD8Cell reports. Medicine · 2026
    Article
  5. Renaissance of antiviral CD8Nature reviews. Immunology · 2026
    Review
  6. Dual Blockade of LILRB1 and LILRB2 Enhances Antiviral Immune Responses in SIV Infection.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  7. Article
  8. Article
  9. Review
  10. Review
  11. Article
  12. Review
  13. Article
  14. Review
  15. HIV controllers, lessons learnt from the lymphoid tissues.Current opinion in HIV and AIDS · 2026
    Review
  16. Article
  17. Review
  18. Early immune responses anticipate HIV rebound and precede viral control.bioRxiv : the preprint server for biology · 2026
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Zahra Kiani *Ragon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.
Jonathan M Urbach *Ragon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0003-0597-2848
Hannah Wisner *Ragon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.ORCID 0009-0006-0329-4317
Mpho J OlatotseRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.
Daniel Y ChangRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0002-8766-3768
Joshua A AcklinRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.
Alicja Piechocka-TrochaRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.
Nathalie BonheurRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.
Ashok KhatriMass General Brigham Peptide Research Core, Massachusetts General Hospital, Charlestown, MA, USA.
Mathias LichterfeldRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-9865-8350
Jesper D GunstDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0002-3787-0259
Ole S SøgaardDepartment of Infectious Diseases, Aarhus University Hospital, Aarhus, Denmark.ORCID 0000-0001-9107-2023
Marina CaskeyLaboratory of Molecular Immunology, The Rockefeller University, New York, NY, USA.ORCID 0000-0003-1727-8693
Michel C NussenzweigHoward Hughes Medical Institute, Chevy Chase, MD, USA.ORCID 0000-0003-0592-8564
Bruce D WalkerRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA.ORCID 0000-0001-6122-9245
David R CollinsRagon Institute of Mass General Brigham, MIT and Harvard, Cambridge, MA, USA. drcollins@mgh.harvard.edu.ORCID 0000-0001-7903-346X

Funding

Multidisciplinary HIV Training ProgramT32AI007387 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel R. Kuritzkes · 1990 to 2026
$8.8M
Single-cell Proteogenomic profiling of HIV-1 reservoir cellsR01AI176579 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI Mathias Lichterfeld · 2023 to 2026
$4.6M
Selection and Evolution of HIV-1 reservoir cells in blood and tissuesR01AI152979 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI ESTES, JACOB D, LICHTERFELD, MATHIAS · 2020 to 2025
$3.8M
Modulating T Cell Activation to Combat HIV PersistenceDP2AI184606 · NIAID · MASSACHUSETTS GENERAL HOSPITAL · PI David Randolph Collins · 2024 to 2026
$1.5M
Mentoring in patient-oriented research to finding a cure for HIV-1 infectionK24AI155233 · NIAID · BRIGHAM AND WOMEN'S HOSPITAL · PI LICHTERFELD, MATHIAS · 2021 to 2025
$958k
NIAID NIH HHS DP2 AI184606NIAID NIH HHS K24 AI155233NIAID NIH HHS R01 AI152979NIAID NIH HHS R01 AI176579NIAID NIH HHS T32 AI007387
6 · The paper itself

Abstract

Interventions to induce lasting human immunodeficiency virus (HIV) remission are needed to obviate the requirement for lifelong antiretroviral therapy. Durable post-intervention control (PIC) of viraemia has been achieved in a subset of people following administration of broadly neutralizing anti-HIV-1 antibodies (bNAb) and analytical interruption of treatment

Indexed as

CD8-Positive T-LymphocytesHIV-1HIV InfectionsStem CellsViremiaBroadly Neutralizing AntibodiesCD4-Positive T-LymphocytesCell ProliferationClone CellsEpitopes, T-LymphocyteFemaleHIV AntibodiesHumansImmunologic MemoryLongitudinal StudiesMaleBroadly Neutralizing AntibodiesEpitopes, T-LymphocyteHIV Antibodies

Identifiers

PMID41326735
PMCPMC12872466

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.