ArticleSurgical endoscopy2026
Intracorporeal vs extracorporeal anastomosis in laparoscopic right colectomy for colon cancer: a prospective multicenter cohort study (the Hemi-D-TREND study).
Article in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03918369 (A Multicenter Controlled Study of the Intracorporeal Mechanical Side-to-side Isoperistaltic Anastomosis Versus Extracorporeal Anastomosis in Laparoscopic Right Hemicolectomy), which is not on this map. Cited by 4 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
A Multicenter Controlled Study of the Intracorporeal Mechanical Side-to-side Isoperistaltic Anastomosis Versus Extracorporeal Anastomosis in Laparoscopic Right Hemicolectomy: HEMI-D-TREND-study
Who cites it
4 citing papers in PubMed.
- Double-stapled intracorporeal anastomosis for minimally invasive right and left colectomies: a standardized technical approach.Surgical endoscopy · 2026Article
- Early implementation and feasibility of Hugo RAS system-assisted right colectomy for right-sided colon cancer: an exploratory propensity score-matched comparison with the da Vinci surgical system.Surgical endoscopy · 2026Article
- Essential Updates 2024-2026: Advances in Colorectal Cancer Surgery.Annals of gastroenterological surgery · 2026Review
- A novel caudal-dorsal approach for laparoscopic right hemicolectomy with complete mesocolic excision.International journal of colorectal disease · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
20 authors.
Funding
Abstract
backgroundAnastomotic leak (AL) is the most severe complication after laparoscopic right colectomy (RC), with historical median rates around 8%. Whether intracorporeal ileocolic anastomosis (ICA) offers advantages over extracorporeal anastomosis (ECA) under standardized, purely laparoscopic conditions remains uncertain. We aimed to compare AL rates and short-term postoperative outcomes between ICA and ECA in laparoscopic RC for colon cancer.
methodsProspective multicenter cohort (TREND-compliant) across 11 hospitals (January 2019-June 2022). Adults with non-metastatic right colon cancer undergoing elective laparoscopic RC were included. Exposure (ICA vs ECA) was determined by each hospital's routine practice. PRIMARY OUTCOME: AL, per predefined clinical, radiologic, or endoscopic criteria. SECONDARY OUTCOMES: conversion to open surgery, length of stay (LOS), complications (Clavien-Dindo), surgical site infection (SSI), and a composite of severe complications (COSC). Analyses used the full cohort; propensity score matching (PSM) was prespecified as a sensitivity analysis.
resultsA total of 438 patients were analyzed: 225 ICA and 213 ECA. AL occurred in 3/225 (1.33%) after ICA and 3/213 (1.41%) after ECA (p = 1.00; risk difference - 0.08 percentage points; 95% CI - 2.1 to 2.3). Conversion was lower with ICA (2.2% vs 7.5%; p = 0.013), while LOS was shorter with ICA (median 4 days; p < 0.001). There were no significant differences in severe morbidity (Clavien-Dindo ≥ III: 5.8% ICA vs 3.8% ECA; p = 0.375), SSI (incisional or organ/space), COSC (6.7% ICA vs 4.2% ECA; p = 0.298), reoperation, or mortality. Findings were consistent in PSM analyses (213:213).
conclusionsIn this prospective multicenter laparoscopic cohort, both intracorporeal and extracorporeal anastomosis achieved anastomotic-leak rates below 2%, with no superiority of one technique over the other regarding leak or severe morbidity. ICA was associated with lower conversion and shorter hospital stay. These results confirm the overall safety and feasibility of both approaches in experienced centers. CLINICALTRIALS: GOV IDENTIFIER: NCT03918369.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.