Evidence map›Paper›PMID 41326720›Full record

ArticleScientific reports2025

Exploring community and expert perceptions of the acceptability of an oropharyngeal gonorrhoea controlled human infection model in Australia.

Eloise Williams, J E Moulton, E Jamrozik, J Prestedge, S Ruth, C K Fairley, M Y Chen, D A Williamson, J S McCarthy, J S Hocking and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Eloise WilliamsDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. eloise.williams3@unimelb.edu.au.
J E MoultonMelbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
E JamrozikDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
J PrestedgeDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
S RuthThorne Harbour Health, Melbourne, VIC, Australia.
C K FairleyMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
M Y ChenMelbourne Sexual Health Centre, Alfred Health, Melbourne, VIC, Australia.
D A WilliamsonDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
J S McCarthyDepartment of Infectious Diseases, The University of Melbourne at the Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
J S HockingMelbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.
L KeoghMelbourne School of Population and Global Health, The University of Melbourne, Melbourne, VIC, Australia.

Funding

Medical Research Future Fund Clinician Researchers Applied Research in Health Grant MRFAR000354National Health and Medical Research Council GNT1172900National Health and Medical Research Council GNT1174555National Health and Medical Research Council GNT2005380National Health and Medical Research Council GNT2016396National Health and Medical Research Council GNT2025840National Health and Medical Research Council GNT2025960Wellcome TrustWellcome Trust [203132], [221719], [320225].
6 · The paper itself

Abstract

The development of an oropharyngeal gonorrhoea controlled human infection model (CHIM) could result in important translational outcomes, including accelerated development of new drugs and vaccines. Ethical study design for such a model requires community consultation, including assessment of the acceptability of the proposed CHIM among key stakeholders. This qualitative study involved: (i) semi-structured interviews and focus groups with individuals who would be eligible for participation in the proposed oropharyngeal gonorrhoea CHIM, defined as healthy men who have sex with men (MSM) aged 18-50 years living in Victoria (Australia); and, (ii) semi-structured interviews with gonorrhoea experts. Data were analysed using inductive thematic analysis supported by NVivo. Twenty-seven semi-structured interviews and one focus group were undertaken with 32 individuals between July and November, 2024, comprising 22 potential CHIM participants, and 10 experts. Overall, an oropharyngeal gonorrhoea CHIM was acceptable to most participants. Financial compensation and including only MSM who do not have sex with women were highlighted as key areas of debate. Participants highlighted that recruitment strategies should be sensitive to the stigma associated with gonorrhoea and history of stigma experienced by MSM. An oropharyngeal gonorrhoea CHIM is acceptable to key stakeholders but must be carefully designed to avoid exacerbation of stigma.

Indexed as

GonorrheaAdolescentAdultAustraliaFemaleFocus GroupsHomosexuality, MaleHumansMaleMiddle AgedPatient Acceptance of Health CareQualitative ResearchSocial StigmaVictoriaYoung Adult

Identifiers

PMID41326720
PMCPMC12796273

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.