Evidence map›Paper›PMID 41326574›Full record

ArticleScientific reports2025

A longitudinal study on the impact of cadmium exposure on quality of life in esophageal squamous cell carcinoma patients in Southern China.

Kaili Yu, Juwei Zhang, Jinsong Zhou, Zhisheng Xiang, Jianbo Lin, Xian-E Peng, Zheng Lin, Zhijian Hu

Abstract read
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In one paragraph

Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Kaili YuDepartment of Quality Control, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Juwei ZhangDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China.
Jinsong ZhouDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China.
Zhisheng XiangDepartment of Epidemiology, Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital, Fuzhou, 350014, China.
Jianbo LinDepartment of Thoracic Surgery, The First Affiliated Hospital of Fujian Medical University, Fuzhou, 350004, China.
Xian-E PengDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China.
Zheng LinDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China. lz@fjmu.edu.cn.
Zhijian HuDepartment of Epidemiology and Health Statistics, Fujian Provincial Key Laboratory of Environment Factors and Cancer, School of Public Health, Fujian Medical University, Fuzhou, 350122, Fujian, China. huzhijian@fjmu.edu.cn.

Funding

the Central government-led local science and technology development special project No. 2020L3009the Grant of Science and Technology of Fujian, China 2019L3006the Natural Science Foundation of Fujian Province No. 2021J01726the Scientific and Technological Innovation Joint Capital Projects of Fujian Province No.2020Y9018
6 · The paper itself

Abstract

Despite evidence linking cadmium (Cd) to poor cancer outcomes, its association with quality of life in esophageal squamous cell carcinoma (ESCC) patients remains unexplored. This study aimed to investigate the association. This prospective cohort analysis includes 414 newly diagnosed ESCC patients with a 6.5-year follow-up. The EORTC QLQ-C30 and EORTC QLQ-OES18 were used to assess health-related quality of life (HRQoL). The QoLR package was used to calculate the HRQoL scores and determine time to deterioration(TTD) events. The effect of plasma Cd level on the HRQoL was assessed using Cox regression analysis. In the longitudinal TTD analysis, after controlling for potential confounders (age, gender, tumor location, clinical/pathological stage, and treatment modalities), higher plasma Cd levels were consistently associated with a significantly increased risk of deterioration in emotional functioning(HR = 1.466, 95%CI:1.079-1.993), eating problems(HR = 1.440, 95%CI: 1.054-1.968), choking when swallowing(HR = 1.637, 95% CI: 1.194-2.244), and trouble with taste(HR = 1.525, 95%CI: 1.093-2.128). These associations remained robust after adjustment for lifestyle and socioeconomic factors and were validated by bootstrap resampling analysis. Plasma Cd level may be a contributing factor to the deterioration of multiple HRQoL indicators.

Indexed as

CadmiumEnvironmental ExposureEsophageal NeoplasmsEsophageal Squamous Cell CarcinomaQuality of LifeAdultAgedChinaFemaleHumansLongitudinal StudiesMaleMiddle AgedProspective StudiesCadmiumCadmiumEsophageal squamous cell carcinomaHealth-related quality of lifeTime to deterioration model

Identifiers

PMID41326574
PMCPMC12775444

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.