ArticleScientific reports2025
Electrospinning of core shell nanofibers using amine modified sericins.
Article in Scientific reports, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
In this study as a renewable resorce, silk sericin (SS), a protein surrounding fibroin fibers in silk, was chemically modified with various amines (e.g., methylamine, butylamine) to improve its functional properties. These modifications, which included nucleophilic substitution reactions, improved its thermal stability, mechanical strength, and biological activity by substituting primary amine groups in place of hydroxyl ions in the structure. Modified SS (M-SS) was then used to produce nanofiber membranes via coaxial electrospinning. In this process, polyvinyl alcohol (PVA) served as the hydrophilic and SS/M-SS carrier polymer to delay biodegradation, while hydrophobic polylactic acid (PLA) and polycaprolactone (PCL) formed the shell to enhance mechanical strength and provide minimum adhesion to wounded tissues. This technique enabled the stable fabrication of core–shell nanofibers containing SS/M-SS, which are typically difficult to electrospin alone. Among the M-SS variants, methylamine-modified sericin (SMAT) yielded nanofibers with the highest tensile strength (0.673 MPa) and 6.44% elongation. The highest thermal resistance was observed in methylamine (SNF7) and butylamine (SNF9) modifications, with SNF7 showing 5% mass loss at 250 °C. The lowest resistance was seen in benzylamine-modified fibers (SNF11) at 220 °C. SNF9 also exhibited the highest cell viability, indicating its potential for biomedical applications.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.