Evidence map›Paper›PMID 41326377›Full record

ArticleTranslational psychiatry2025

Relationships between local metabolic activity and distributed functional connectivity in major depressive disorder.

Wendy Sun, Anne Billot, Stephanie McMains, Kathryn Rodrigues, Rodrigo M Braga, David Izquierdo-Garcia, Mark C Eldaief

Abstract read
In one paragraph

Article in Translational psychiatry, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Wendy Sun *Center for Brain Science, Neuroimaging Facility, Harvard University, Cambridge, MA, 02138, USA.ORCID http://orcid.org/0000-0001-7350-964X
Anne Billot *Harvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0000-0002-6356-2719
Stephanie McMainsCognitive Neuroimaging Center, Boston University, Boston, MA, 02215, USA.ORCID http://orcid.org/0000-0003-3079-7658
Kathryn RodriguesHarvard Medical School, Boston, MA, 02115, USA.ORCID http://orcid.org/0009-0009-2628-659X
Rodrigo M BragaFeinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.ORCID http://orcid.org/0000-0003-2671-7096
David Izquierdo-GarciaAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital, Charlestown, MA, 02129, USA.ORCID http://orcid.org/0000-0003-0763-8827
Mark C EldaiefCenter for Brain Science, Neuroimaging Facility, Harvard University, Cambridge, MA, 02138, USA. mark.eldaief@mgh.harvard.edu.ORCID http://orcid.org/0000-0002-4919-2897

Funding

Probing the Functional and Behavioral Impact of Precision Circuit Modulation in Neuropsychiatric DisordersR01MH129367 · NIMH · MASSACHUSETTS GENERAL HOSPITAL · PI Mark Christian Eldaief · 2022 to 2026
$4.1M
Investigation of cortico-limbic networks and their dynamics in major depressive dK23MH099413 · NIMH · BRIGHAM AND WOMEN'S HOSPITAL · PI ELDAIEF, MARK CHRISTIAN · 2012 to 2016
$930k
CAUSAL MECHANISMS OF DISTRIBUTED BRAIN NETWORK FUNCTION DURING EPISODIC MEMORY RETRIEVALR00MH117226 · NIMH · NORTHWESTERN UNIVERSITY AT CHICAGO · PI BRAGA, RODRIGO M · 2020 to 2022
$744k
NIMH NIH HHS K23 MH099413NIMH NIH HHS R00 MH117226NIMH NIH HHS R01 MH129367U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) K23MH099413U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) MH129367U.S. Department of Health & Human Services | NIH | National Institute of Mental Health (NIMH) R00MH117226
6 · The paper itself

Abstract

Functional neuroimaging studies have described changes in local activity or in distributed connectivity in Major Depressive Disorder (MDD). We studied the interactions between these levels of neural organization to reveal novel pathobiological signatures of MDD. We scanned 21 unmedicated MDD subjects and 21 matched non-depressed controls at rest with simultaneous

Indexed as

BrainMajor Depressive DisorderNerve NetAdultCase-Control StudiesConnectomeFemaleFluorodeoxyglucose F18Functional NeuroimagingHumansMagnetic Resonance ImagingMaleMiddle AgedPositron-Emission TomographyYoung AdultFluorodeoxyglucose F18

Identifiers

PMID41326377
PMCPMC12873300

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.